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Description
How It Works
Activase (alteplase) is a tissue plasminogen activator (tPA) used to treat acute ischemic stroke, myocardial infarction (heart attack), and pulmonary embolism. It works by converting plasminogen to plasmin, an enzyme that breaks down clots. By promoting the dissolution of clots, Activase helps to restore blood flow to the affected areas, reducing damage and improving outcomes in acute thrombotic events.List of Side Effects
- Bleeding at the injection site
- Internal bleeding (gastrointestinal, genitourinary)
- Intracranial hemorrhage
- Hypotension (low blood pressure)
- Nausea
- Vomiting
- Allergic reactions (rash, urticaria, anaphylaxis)
- Oropharyngeal pain
- Cardiac arrhythmias
List of Indications
- Acute ischemic stroke within 3 hours of symptom onset
- Acute myocardial infarction
- Acute massive pulmonary embolism
List of Contraindications
- Active internal bleeding
- History of recent stroke
- Recent (within 3 months) intracranial or intraspinal surgery or serious head trauma
- Known bleeding diathesis
- Severe uncontrolled hypertension
- Current use of anticoagulants with an elevated INR
Price in Different Countries
Country | Price (USD) | Reference Website |
---|---|---|
United States | $2,800 | GoodRx |
United Kingdom | ?2,000 | NICE BNF |
Canada | $3,000 CAD | CanadaDrugs.com |
Australia | $3,500 AUD | PBS Australia |
India | ?200,000 INR | 1mg |
Pakistan | ? 450,000 PKR | Dawaai.pk |
Top 5 Global Brands
- Activase (Alteplase) – Genentech
- Retavase (Reteplase) – Chiesi
- TNKase (Tenecteplase) – Genentech
- Metalyse (Tenecteplase) – Boehringer Ingelheim
- Streptase (Streptokinase) – Sanofi
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