activase (alteplase) injection


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How It Works

Activase (alteplase) is a tissue plasminogen activator (tPA) used to treat acute ischemic stroke, myocardial infarction (heart attack), and pulmonary embolism. It works by converting plasminogen to plasmin, an enzyme that breaks down clots. By promoting the dissolution of clots, Activase helps to restore blood flow to the affected areas, reducing damage and improving outcomes in acute thrombotic events.

List of Side Effects

  • Bleeding at the injection site
  • Internal bleeding (gastrointestinal, genitourinary)
  • Intracranial hemorrhage
  • Hypotension (low blood pressure)
  • Nausea
  • Vomiting
  • Allergic reactions (rash, urticaria, anaphylaxis)
  • Oropharyngeal pain
  • Cardiac arrhythmias

List of Indications

  • Acute ischemic stroke within 3 hours of symptom onset
  • Acute myocardial infarction
  • Acute massive pulmonary embolism

List of Contraindications

  • Active internal bleeding
  • History of recent stroke
  • Recent (within 3 months) intracranial or intraspinal surgery or serious head trauma
  • Known bleeding diathesis
  • Severe uncontrolled hypertension
  • Current use of anticoagulants with an elevated INR

Price in Different Countries

Country Price (USD) Reference Website
United States $2,800 GoodRx
United Kingdom ?2,000 NICE BNF
Canada $3,000 CAD
Australia $3,500 AUD PBS Australia
India ?200,000 INR 1mg
Pakistan ? 450,000 PKR

Top 5 Global Brands

  1. Activase (Alteplase) – Genentech
  2. Retavase (Reteplase) – Chiesi
  3. TNKase (Tenecteplase) – Genentech
  4. Metalyse (Tenecteplase) – Boehringer Ingelheim
  5. Streptase (Streptokinase) – Sanofi
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