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  • Adempas (riociguat) 2.5 mg film-coated tablets

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    Description

    How It Works

    Adempas works by stimulating the enzyme soluble guanylate cyclase (sGC), which is a key regulator of the nitric oxide (NO) signaling pathway. By activating sGC, riociguat increases the levels of cyclic guanosine monophosphate (cGMP), leading to relaxation of the smooth muscle cells in the blood vessels. This relaxation results in the dilation of pulmonary arteries, thereby reducing the pulmonary arterial pressure and improving blood flow. This mechanism helps alleviate symptoms associated with pulmonary hypertension and enhances the patient?s ability to exercise.

    Side Effects

    • Headache
    • Dizziness
    • Nausea
    • Diarrhea
    • Hypotension (low blood pressure)
    • Gastroesophageal reflux disease (GERD)
    • Peripheral edema (swelling of the extremities)
    • Anemia

    Indications

    • Chronic thromboembolic pulmonary hypertension (CTEPH) ? for patients with WHO Group 4 who are not operable or who have persistent or recurrent CTEPH after surgical treatment
    • Pulmonary arterial hypertension (PAH) ? for patients with WHO Group 1 to improve exercise capacity and WHO functional class

    Contraindications

    • Use with nitrates or nitric oxide donors (e.g., amyl nitrite)
    • Use with phosphodiesterase inhibitors (e.g., sildenafil, tadalafil)
    • Pregnancy ? due to risk of fetal harm
    • Severe hepatic impairment
    • Hypersensitivity to riociguat or any of its components

    Price Comparison in Different Countries

    Country Price (per tablet) Reference
    Pakistan Approximately PKR 3,500 medicalstore.ae Pakistan
    United States USD 250 GoodRx
    United Kingdom GBP 200 NHS UK
    Canada CAD 300 Health Canada
    Australia AUD 350 PBS Australia

    Top 5 Global Brands

    1. Novartis
    2. Pfizer
    3. Roche
    4. Sanofi
    5. GlaxoSmithKline (GSK)

    Conclusion

    Adempas (riociguat) is a critical medication for managing chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). By stimulating the soluble guanylate cyclase (sGC) enzyme, it helps to dilate pulmonary arteries, thus reducing blood pressure in the lungs and improving exercise capacity. Patients using Adempas should be aware of potential side effects and contraindications, and discuss these with their healthcare provider. The cost of Adempas varies across different countries, and patients should explore financial assistance programs where necessary. Consult with your healthcare provider to determine the most appropriate treatment options for your condition.  
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    Adempas (riociguat) 2.5 mg film-coated tablets
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