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  • Aldurazyme (laronidase) injection 2.9 mg/5ml

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    Description

    Aldurazyme (Laronidase) is a prescription enzyme replacement therapy used to treat mucopolysaccharidosis type I (MPS I), a rare genetic disorder caused by a deficiency of the enzyme alpha-L-iduronidase. It is administered via injection, with each vial containing 2.9 mg of laronidase in 5 ml of solution. The drug helps to break down certain complex carbohydrates that accumulate in the body due to the enzyme deficiency, which can help alleviate symptoms and slow disease progression.

    How It Works

    Laronidase, the active ingredient in Aldurazyme, is a recombinant form of the human enzyme alpha-L-iduronidase. In patients with MPS I, this enzyme is deficient or absent, leading to the accumulation of glycosaminoglycans (GAGs) in various tissues and organs. Laronidase works by supplementing the body with a functional form of the enzyme, which helps to break down GAGs into simpler compounds that can be more easily eliminated from the body. This process helps to reduce the build-up of these substances, alleviating symptoms and potentially improving overall function.

    Side Effects

    Common side effects of Aldurazyme include:
    • Fever
    • Chills
    • Headache
    • Rash
    • Swelling at the injection site
    • Nausea
    Serious side effects may include:
    • Allergic reactions, including anaphylaxis
    • Severe skin reactions
    • Infusion-related reactions (e.g., difficulty breathing, chest pain)
    • Elevated liver enzymes
    Patients should seek immediate medical attention if they experience severe or persistent side effects.

    Indications

    Aldurazyme is indicated for:
    • Treatment of patients with mucopolysaccharidosis type I (MPS I), including severe, intermediate, and mild forms of the disease.

    Contraindications

    Aldurazyme should not be used in patients with:
    • Known hypersensitivity to laronidase or any of the excipients in the formulation.
    • Severe allergic reactions to previous doses of Aldurazyme.
    Patients with a history of hypersensitivity reactions should be monitored closely during treatment.

    Price in Different Countries

    Country Price (per 2.9 mg/5 ml Injection) References
    United States $24,000 – $26,000 per vial GoodRx Aldurazyme Price
    United Kingdom £18,000 – £20,000 per vial NHS Aldurazyme Price
    Australia $30,000 AUD per vial PBS Aldurazyme Price
    India ₹1,80,000 – ₹2,00,000 per vial 1mg Aldurazyme Price
    Canada $28,000 – $30,000 CAD per vial Canadian Pharmacy Aldurazyme Price

    Top 5 Global Brands

    In the field of enzyme replacement therapies and similar treatments, the top global brands include:
    • Fabrazyme (Agalsidase beta) – Sanofi: Used for treating Fabry disease.
    • Myozyme (Alglucosidase alfa) – Sanofi: Used for treating Pompe disease.
    • Elaprase (Idursulfase) – Takeda: Used for treating Hunter syndrome.
    • VPRIV (Velaglucerase alfa) – Takeda: Used for treating Gaucher disease.
    • Brineura (Cerliponase alfa) – BioMarin: Used for treating Batten disease.
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    Aldurazyme (laronidase) injection 2.9 mg/5ml
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