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ALECENSA (alectinib) is a medication used to treat non-small cell lung cancer (NSCLC) that has a specific genetic mutation known as ALK-positive (anaplastic lymphoma kinase-positive). Here’s an overview: Pros:
  1. Targeted Therapy: ALECENSA is a targeted therapy that specifically inhibits the activity of the ALK protein, which is involved in the growth and spread of cancer cells in ALK-positive NSCLC. By targeting this specific genetic mutation, ALECENSA can effectively slow down or stop the progression of the disease.
  2. High Efficacy: Clinical trials have demonstrated that ALECENSA is highly effective in treating ALK-positive NSCLC, with high response rates and prolonged progression-free survival compared to chemotherapy.
  3. Oral Administration: ALECENSA is taken orally in the form of capsules, making it convenient for patients to take at home without the need for frequent hospital visits.
  4. Well-Tolerated: ALECENSA is generally well-tolerated, with manageable side effects. Common side effects may include fatigue, constipation, muscle pain, and peripheral edema. Serious side effects such as liver problems and lung inflammation are less common but require monitoring.
  1. Cost: ALECENSA can be expensive, especially for those without adequate insurance coverage. The price can vary depending on factors such as location and insurance plan.
  2. Drug Interactions: ALECENSA may interact with other medications, including certain over-the-counter drugs, prescription medications, and herbal supplements. It’s important for patients to inform their healthcare provider about all the medications they are taking to avoid potential interactions.
  3. Resistant Mutations: Some patients may develop resistance to ALECENSA over time, leading to disease progression. In such cases, alternative treatment options may need to be considered.
Price Comparison: The price of ALECENSA 150 mg capsules can vary significantly depending on the country, pharmacy, and insurance coverage. In the United States, for example, the average wholesale price (AWP) for ALECENSA can range from $10,000 to $12,000 per month. However, patients may be eligible for financial assistance programs from the manufacturer or other sources to help cover the cost. Patients should discuss the potential benefits and risks of ALECENSA with their healthcare provider, as well as any concerns about affordability. Close monitoring is essential to manage side effects and ensure the best treatment outcomes.
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