ANZATAX 30 MG 5 ML FLC

ANZATAX (Docetaxel) is an intravenous medication used in the treatment of various cancers. It is a member of the taxane class of chemotherapy drugs and is typically administered as an infusion. ANZATAX is formulated as a 100 mg/16.7 mL solution, making it suitable for direct intravenous administration.

How ANZATAX Works

Mechanism of Action

1. Microtubule Stabilization:
   • ANZATAX, which contains docetaxel, works by binding to the tubulin component of microtubules. This binding stabilizes the microtubules and prevents their disassembly. Microtubules are critical components of the cell’s cytoskeleton and play a crucial role in cell division.
2. Inhibition of Cell Division:
   • By stabilizing microtubules, ANZATAX effectively halts the mitotic spindle formation, which is necessary for chromosome segregation during cell division. This results in cell cycle arrest in the metaphase stage, leading to cell death.
3. Induction of Apoptosis:
   • The interference with normal cell division triggers apoptosis (programmed cell death) in cancer cells. This mechanism reduces the number of malignant cells and helps to manage the cancerous growth.
4. Targeting Cancer Cells:
   • ANZATAX primarily targets rapidly dividing cancer cells, making it effective in treating cancers that are characterized by high rates of cell proliferation.

Side Effects

Common Side Effects

• Nausea and Vomiting:
  • Patients may experience gastrointestinal symptoms such as nausea and vomiting following infusion.
• Fatigue:
  • General tiredness and weakness are common side effects.
• Hair Loss:
  • Temporary hair loss can occur, which typically regrows after treatment.
• Diarrhea:
  • Gastrointestinal issues including diarrhea may be observed.
• Appetite Loss:
  • Reduced appetite leading to weight loss is possible.

Serious Side Effects

• Bone Marrow Suppression:
  • ANZATAX can cause significant suppression of bone marrow activity, leading to anemia, leukopenia, and thrombocytopenia. Regular blood monitoring is required.
• Infection Risk:
  • Due to reduced white blood cell counts, patients are at a higher risk of infections.
• Severe Allergic Reactions:
  • Anaphylaxis or severe allergic reactions, including rash, itching, and swelling, can occur.
• Liver Toxicity:
  • Elevated liver enzymes and liver function abnormalities may be observed in some patients.
• Fluid Retention:
  • Peripheral edema or fluid retention in the body can occur, requiring management.

Indications

ANZATAX is indicated for the treatment of various cancers. Its use depends on the specific type and stage of the cancer being treated.

Approved Indications

• Breast Cancer:
  • Used in combination with other medications for the treatment of breast cancer, particularly in cases that have not responded to other therapies.
• Non-Small Cell Lung Cancer (NSCLC):
  • Effective in treating non-small cell lung cancer, especially in advanced stages.
• Prostate Cancer:
  • Utilized in combination with other therapies for treating hormone-refractory prostate cancer.
• Ovarian Cancer:
  • Prescribed for treating ovarian cancer, often in combination with other chemotherapy agents.
• Head and Neck Cancers:
  • Indicated for the treatment of certain head and neck cancers.

Contraindications

Certain conditions and patient factors make the use of ANZATAX unsuitable due to potential risks.

Contraindications

• Hypersensitivity:
  • Known hypersensitivity or allergy to docetaxel or any of the formulation components.
• Severe Bone Marrow Depression:
  • Existing severe bone marrow suppression or hematological disorders.
• Severe Liver Dysfunction:
  • Contraindicated in patients with severe liver impairment due to the risk of exacerbating liver toxicity.
• Pregnancy:
  • ANZATAX should not be used during pregnancy due to potential harm to the fetus.
• Severe Infections:
  • Active severe infections should be managed prior to starting treatment with ANZATAX.

Price in Different Countries

The price of ANZATAX varies across different countries and regions. Below is a table with approximate prices and references for further details.

Country	Price (Per 100 mg/16.7 mL)	Reference
United States	$2,000 – $2,500	GoodRx
United Kingdom	£1,500 – £2,000	NHS UK
Canada	CAD $2,200 – $2,700	Canada Pharmacy
Australia	AUD $2,800 – $3,200	PBS Australia
India	₹1,50,000 – ₹1,80,000	1mg

Top 5 Global Brands

While ANZATAX is a leading brand of docetaxel, several other brands and generics are available worldwide.

1. Taxotere (Docetaxel) – Sanofi

• The original brand and most well-known version of docetaxel.

2. Docefrez – Fresenius Kabi

• A widely recognized brand offering docetaxel.

3. Docetaxel Accord – Accord Healthcare

• A reputable brand for docetaxel.

4. Docetaxel Sun – Sun Pharmaceutical

• Another reliable brand providing docetaxel.

5. Docetaxel Actavis – Actavis

• • A cost-effective option for docetaxel treatment.