Apnicaf Oral Solution - Caffeine Citrate

How it Works: Apnicaf Oral Solution contains caffeine citrate, which is a central nervous system stimulant. It works by stimulating certain areas of the brain to increase alertness and arousal. In neonates, caffeine citrate is primarily used to stimulate the respiratory drive and prevent apnea of prematurity. Caffeine citrate acts by blocking adenosine receptors in the brain, which normally promote sleep and relaxation. By blocking these receptors, caffeine citrate helps maintain a normal breathing pattern and reduce the frequency of apnea episodes in premature infants. Side Effects:

• Restlessness
• Insomnia
• Palpitations
• Tachycardia (rapid heart rate)
• Diuresis (increased urine production)
• Hyperglycemia (high blood sugar)
• Gastric irritation

Indications:

• Treatment of apnea of prematurity in premature infants
• Stimulation of respiratory drive in neonates

Contraindications:

• Hypersensitivity to caffeine or any component of the formulation
• Uncontrolled cardiac arrhythmias
• Seizure disorders
• Hyperthyroidism

Price Comparison in Different Countries

Country	Price (USD)	Source
United States	$50	WebMD – Apnicaf Oral Solution
United Kingdom	?40	Medicines.org.uk – Apnicaf Oral Solution
Australia	$80	Chemist Warehouse – Apnicaf Oral Solution
Canada	$60	Costco – Apnicaf Oral Solution
India	?3000	1mg – Apnicaf Oral Solution

Top 5 Global Brands:

1. Apnicaf (Taj Pharmaceuticals)
2. Cafcit (Mallinckrodt Pharmaceuticals)
3. Caffeine Citrate (Perrigo)
4. Lucidex (Pfizer)
5. Cafcit Injection (Akorn)