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  • Atriance (Nelarabine) Injection

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    Description

    Atriance (Nelarabine) is an antineoplastic (anti-cancer) medication used in chemotherapy. It belongs to the class of drugs called antimetabolites and is specifically designed to treat certain types of leukemia and lymphoma, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). Nelarabine is a prodrug that is converted into its active form, Ara-GTP, within the body, where it targets and destroys cancerous T-cells.

    How It Works

    Atriance (Nelarabine) works by interfering with the DNA synthesis in T-cells, particularly those that are cancerous. As a purine nucleoside analog, nelarabine gets metabolized into an active form, Ara-GTP, within the cell. This active compound is then incorporated into the DNA of rapidly dividing cancer cells, disrupting their replication process and ultimately leading to cell death. By selectively targeting T-cells, Atriance helps to destroy malignant cells, slowing down or stopping the progression of leukemia and lymphoma.

    Indications

    Atriance is indicated for the treatment of:
    • T-cell Acute Lymphoblastic Leukemia (T-ALL): A fast-growing form of cancer in which too many immature T-cells are found in the blood and bone marrow.
    • T-cell Lymphoblastic Lymphoma (T-LBL): A type of non-Hodgkin lymphoma where T-lymphocytes (a type of white blood cell) become cancerous.
    These indications typically apply when the disease has not responded to, or has relapsed after, at least two chemotherapy treatments.

    Side Effects

    Common side effects of Atriance include:
    • Fatigue
    • Nausea
    • Vomiting
    • Diarrhea
    • Constipation
    • Decreased appetite
    • Headache
    • Dizziness
    • Anemia (low red blood cell count)
    • Thrombocytopenia (low platelet count)
    Serious side effects may include:
    • Peripheral Neuropathy: Numbness, tingling, or pain in the hands and feet, sometimes leading to difficulty walking.
    • Central Nervous System Toxicity: This can include symptoms such as confusion, seizures, and coma.
    • Severe Bone Marrow Suppression: Leading to increased risk of infection due to low white blood cell counts (neutropenia).
    • Severe Infections: Particularly in immunocompromised patients.

    Contraindications

    Atriance is contraindicated in:
    • Patients with known hypersensitivity to nelarabine or any of the excipients in the product.
    • Pregnancy and Lactation: Nelarabine may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should use effective contraception during and after treatment.
    • Severe Hepatic or Renal Impairment: The drug is primarily metabolized in the liver and excreted by the kidneys, so caution is advised in patients with liver or kidney dysfunction.

    Pricing Table (in Different Countries)

    The table below provides an approximate cost comparison for Atriance (Nelarabine) Injection across several countries. Prices can fluctuate based on health insurance coverage and healthcare system differences.

    Atriance (Nelarabine) Injection Price Comparison

    Country Price (USD) Reference
    United States $10,500 per vial GoodRx
    United Kingdom £7,800 per vial NICE
    Canada CAD $13,000 per vial CADTH
    Australia AUD $14,000 per vial PBS
    Germany €9,500 per vial G-BA

    Top 5 Global Brands

    1. Novartis: The manufacturer of Atriance, Novartis is a global leader in innovative therapies for cancer, particularly in oncology and hematology.
    2. Pfizer: A major player in the oncology market, offering several targeted therapies and chemotherapy agents for various cancers.
    3. Roche: Known for its strong oncology portfolio, including treatments for leukemia, lymphoma, and other types of cancer.
    4. Amgen: Focuses on biotechnology-based solutions, providing oncology therapies that help manage and treat a range of cancer types.
    5. Bristol-Myers Squibb: A key developer of cancer treatments, especially immunotherapies and chemotherapy agents for hematologic malignancies.
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