Austedo (deutetrabenazine) 12mg Tablet


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How It Works

Austedo (deutetrabenazine) is a vesicular monoamine transporter 2 (VMAT2) inhibitor. It works by decreasing the amount of dopamine available in nerve cells, thereby reducing the abnormal movements associated with Huntington?s disease and tardive dyskinesia. By inhibiting VMAT2, deutetrabenazine prevents the transport of dopamine into synaptic vesicles, leading to decreased dopamine release and subsequent reduction in motor activity.

List of Side Effects

  • Somnolence (sleepiness)
  • Diarrhea
  • Dry mouth
  • Fatigue
  • Insomnia
  • Anxiety
  • Depression
  • Nasopharyngitis
  • Arthralgia (joint pain)
  • Urinary tract infection

List of Indications

  • Treatment of chorea associated with Huntington?s disease
  • Treatment of tardive dyskinesia in adults

List of Contraindications

  • Patients with Huntington?s disease who are suicidal or have untreated or inadequately treated depression
  • Patients with hepatic impairment
  • Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
  • Concomitant use with reserpine or within 20 days of discontinuing reserpine

Price in Different Countries

Country Price (USD) Reference Website
United States $8,000 GoodRx
United Kingdom ?6,200 NICE BNF
Canada $10,500 CAD
Australia $11,000 AUD PBS Australia
India ?600,000 INR 1mg
Pakistan ? 1,300,000 PKR

Top 5 Global Brands

  1. Austedo (Deutetrabenazine) – Teva Pharmaceuticals
  2. Xenazine (Tetrabenazine) – Lundbeck
  3. Ingrezza (Valbenazine) – Neurocrine Biosciences
  4. Abilify (Aripiprazole) – Otsuka Pharmaceutical
  5. Risperdal (Risperidone) – Janssen Pharmaceuticals
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