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  • Benepali 50 mg solution for injection in pre-filled pen

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    Description

    Benepali is a biosimilar to Enbrel (etanercept), used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine. Each pre-filled pen contains 50 mg of etanercept, designed for subcutaneous administration. Benepali is used in various inflammatory conditions, particularly in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

    How It Works

    Benepali works by binding to and inhibiting TNF-alpha, a pro-inflammatory cytokine involved in the inflammatory processes of autoimmune diseases. TNF-alpha is produced by cells of the immune system and contributes to inflammation and joint damage in rheumatoid arthritis and other conditions. By blocking the activity of TNF-alpha, Benepali reduces inflammation, alleviates symptoms, and prevents disease progression.

    Indications

    • Rheumatoid arthritis (moderate to severe) in adults
    • Psoriatic arthritis
    • Ankylosing spondylitis
    • Non-radiographic axial spondyloarthritis
    • Plaque psoriasis in adults and children
    • Juvenile idiopathic arthritis

    Contraindications

    • Known hypersensitivity to etanercept or any of the excipients
    • Sepsis or risk of sepsis
    • Active infections, including chronic or localized infections

    Side Effects

    • Injection site reactions (redness, itching, swelling)
    • Infections (upper respiratory tract infections, sinusitis)
    • Headache
    • Nausea
    • Rash
    • Abdominal pain
    • Allergic reactions
    • Serious infections (pneumonia, tuberculosis)
    • Blood disorders (anemia, leukopenia)
    • Heart failure
    • Autoimmune disorders (lupus-like syndrome)

    Price in Different Countries

    Country Price (per pre-filled pen) References
    United States $2,000 GoodRx Benepali Price
    United Kingdom £1,600 NHS Benepali Price
    Canada $1,800 Canada Drugs Benepali Price
    Australia $1,900 PBS Benepali Price
    India ₹140,000 1mg Benepali Price

    Top 5 Global Brands

    • Benepali (Samsung Bioepis/Biogen): A biosimilar to Enbrel, used to treat various autoimmune diseases.
    • Enbrel (Amgen/Pfizer): The original brand of etanercept, widely used for treating rheumatoid arthritis and other inflammatory conditions.
    • Humira (AbbVie): A monoclonal antibody targeting TNF-alpha, used for treating rheumatoid arthritis, Crohn’s disease, and other autoimmune diseases.
    • Remicade (Janssen Biotech): An anti-TNF monoclonal antibody used for treating autoimmune diseases such as rheumatoid arthritis and Crohn’s disease.
    • Simponi (Janssen Biotech): Another anti-TNF agent used for treating various inflammatory conditions, including rheumatoid arthritis and ulcerative colitis.
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    Benepali 50 mg solution for injection in pre-filled pen
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