benlysta (belimumab) for injection 120mg

How It Works

Benlysta targets and inhibits the activity of the BLyS protein. BLyS is crucial for the survival and development of B-cells, a type of white blood cell involved in the immune response. By blocking BLyS, Benlysta reduces the number of abnormal B-cells, thereby diminishing the autoimmune response and inflammation associated with lupus.

Side Effects

• Infusion reactions (e.g., fever, chills, nausea)
• Nausea
• Diarrhea
• Fever
• Nasopharyngitis
• Bronchitis
• Insomnia
• Urinary tract infection
• Depression

Indications

• Systemic lupus erythematosus (SLE) in adults and children aged 5 years and older
• Lupus nephritis in adults

Contraindications

• Hypersensitivity to belimumab or any of the excipients
• Active severe infections

Price Comparison in Different Countries

Country	Price (per vial of 120mg)	Reference
Pakistan	Approximately PKR 80,000	Dawaai Pakistan
United States	USD 1,200	GoodRx
United Kingdom	GBP 900	NHS UK
Canada	CAD 1,500	PharmaChoice Canada
Australia	AUD 1,700	PBS Australia

Top 5 Global Brands

1. GlaxoSmithKline (GSK)
2. Roche
3. Pfizer
4. Novartis
5. Johnson & Johnson

Conclusion

Benlysta (Belimumab) for injection 120mg is a significant advancement in the treatment of systemic lupus erythematosus (SLE) and lupus nephritis. By targeting and inhibiting the BLyS protein, it effectively reduces the abnormal B-cell activity responsible for the autoimmune response in lupus. Despite its efficacy, Benlysta comes with a range of potential side effects and contraindications that need careful management by healthcare providers. The cost of Benlysta varies significantly across different countries, reflecting the global disparity in access to advanced medical treatments. Patients should discuss with their healthcare providers to determine if Benlysta is the appropriate treatment for their condition and explore possible financial assistance options if needed.