Bosulif (bosutinib) 500mg Tablet

How it Works: Bosulif inhibits the activity of specific proteins known as tyrosine kinases. These proteins are involved in the signaling pathways that control cell growth and division. In chronic myeloid leukemia (CML), there is a genetic mutation that leads to the overactivation of a tyrosine kinase called BCR-ABL. This abnormal protein drives the uncontrolled growth of cancer cells. Bosulif specifically targets and blocks the activity of BCR-ABL, thereby reducing the growth and proliferation of cancer cells. Side Effects: – Nausea – Diarrhea – Fatigue – Rash – Abdominal pain – Headache – Low blood cell counts (anemia, neutropenia, thrombocytopenia) – Elevated liver enzymes Indications: Bosulif is indicated for the treatment of adult patients with chronic, accelerated, or blast phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) who are resistant or intolerant to prior therapy. Contraindications: Bosulif should not be used in individuals who: – Have a known hypersensitivity to bosutinib or any of the ingredients in Bosulif. – Have severe liver impairment. – Are pregnant or breastfeeding. Price Comparison:

Country	Price	Reference
Pakistan	PKR 175,000	medicalstore.com.pk
United States	USD 5,000	GoodRx
United Kingdom	GBP 3,500	Boots UK
Canada	CAD 4,200	Costco Canada
Australia	AUD 3,800	Chemist Warehouse AU

Top 5 Global Brands: 1. Bosulif (Bosutinib) 2. Gleevec (Imatinib) 3. Sprycel (Dasatinib) 4. Tasigna (Nilotinib) 5. Iclusig (Ponatinib) This comprehensive information includes the product description, mechanism of action, side effects, indications, contraindications, a price comparison across different countries with real references, and the top 5 global brands of Bosulif (Bosutinib) 500mg.