Braftovi (encorafenib) is a medication used in the treatment of certain types of cancer, specifically melanoma with a BRAF V600E or BRAF V600K mutation. It is typically used in combination with other medications, such as binimetinib, to improve treatment efficacy.
Mechanism of Action: Braftovi is a BRAF inhibitor that works by targeting and inhibiting the activity of mutated BRAF proteins. BRAF is a protein involved in cell signaling pathways that regulate cell growth and division. Mutations in the BRAF gene, such as the V600E and V600K mutations, can lead to uncontrolled cell growth and contribute to the development of cancer. By inhibiting mutated BRAF proteins, Braftovi helps to slow down or stop the growth of cancer cells.
Benefits: The benefits of Braftovi include:
- Treatment of unresectable or metastatic melanoma with a BRAF V600E or BRAF V600K mutation.
- Improvement in progression-free survival and overall survival compared to standard treatments in clinical trials.
- Potential for tumor shrinkage and symptom relief in patients with advanced melanoma.
Dosage and Administration: Braftovi is typically taken orally in the form of capsules. The recommended dosage is 450 mg (three capsules) once daily, with or without food. The treatment duration may vary depending on the patient’s response to therapy and any side effects experienced. Dosage adjustments or discontinuation of treatment may be necessary based on individual patient factors.
Suitability: Braftovi is indicated for patients with melanoma who have specific BRAF mutations (V600E or V600K). The suitability of Braftovi for an individual patient is determined based on factors such as mutation status, disease stage, prior treatments received, overall health status, and any underlying medical conditions.
Availability and Pricing: Braftovi is available by prescription only and is typically obtained from pharmacies or medical facilities where oncology medications are dispensed. Pricing can vary between countries and regions, and specific pricing information would need to be obtained from pharmaceutical databases, local pharmacies, or healthcare providers.
Braftovi represents a significant advancement in the treatment of melanoma, particularly for patients with BRAF-mutated disease. However, like all medications, it may cause side effects, and patients should be closely monitored by healthcare professionals during treatment.
BRAFTOVI 75 MG SERT KAPSUL