Briviact 50 mg Film-coated Tablets

Briviact (brivaracetam) is an antiepileptic medication used in the treatment of epilepsy, particularly for partial-onset seizures in patients aged 4 years and older. It belongs to the class of drugs known as antiepileptic drugs (AEDs), and its primary action is to reduce the frequency of seizures by interacting with neurotransmitters in the brain.

How It Works

Briviact works by targeting a protein known as synaptic vesicle protein 2A (SV2A) in the brain. This protein is involved in the release of neurotransmitters that help in nerve signaling. By binding to SV2A, brivaracetam modulates neurotransmitter release and stabilizes electrical activity in the brain, helping to prevent seizures.

Mechanism of Action:

1. SV2A Binding: Brivaracetam binds to SV2A, a protein found in synaptic vesicles of neurons, which plays a key role in the regulation of neurotransmitter release.
2. Modulation of Excitability: By modulating SV2A, Briviact helps reduce the excessive neuronal firing that can trigger seizures.
3. Antiepileptic Effects: The modulation of neurotransmitter release stabilizes the electrical activity in the brain, thus reducing the likelihood of seizures in epilepsy patients.

Side Effects

Briviact is generally well-tolerated, but like all medications, it can cause side effects. The following are some common and serious side effects associated with its use.

Common Side Effects:

• Drowsiness: Feeling unusually sleepy or tired.
• Dizziness: Lightheadedness or unsteadiness.
• Fatigue: General feeling of weakness or exhaustion.
• Nausea: Feeling queasy or sick to the stomach.
• Irritability: Increased agitation or mood changes.

Serious Side Effects:

• Suicidal Thoughts: Some patients may experience worsening depression, suicidal thoughts, or other mood changes.
• Coordination Problems: Difficulty with coordination, including walking and performing everyday tasks.
• Severe Allergic Reactions: Signs include rash, itching, swelling, severe dizziness, and trouble breathing.

If any of these side effects persist or worsen, it’s important to consult a healthcare provider immediately.

Indications

Briviact is primarily indicated for the management of epilepsy, specifically for controlling partial-onset seizures.

Approved Indications:

1. Partial-Onset Seizures: In adults and children aged 4 years and older with epilepsy. Briviact is often used as an adjunctive therapy alongside other antiepileptic medications.
2. Epilepsy: Generalized epilepsy, where Briviact helps in managing uncontrolled seizure activity.

Contraindications

There are certain conditions where the use of Briviact may not be appropriate. Contraindications should be carefully reviewed by a healthcare provider.

Contraindications:

1. Hypersensitivity: Briviact should not be used in individuals who are hypersensitive to brivaracetam or any of its components.
2. Liver Disease: Patients with severe hepatic impairment may need dosage adjustments or may be advised against using Briviact.
3. Severe Depression or Suicidal Behavior: Caution is advised in patients with a history of suicidal thoughts or severe depression, as AEDs like Briviact can worsen these conditions.

Price in Different Countries

The price of Briviact varies across different regions due to healthcare systems, insurance coverage, and availability. Below is a table with approximate prices in various countries, along with reference links to the websites where the information was found.

Country	Price (Per Dose)	Reference
United States	$850 – $900 (30 tablets)	GoodRx
United Kingdom	£600 – £650 (30 tablets)	NHS UK
Australia	AUD $900 – $950 (30 tablets)	PBS Australia
India	INR ₹58,000 – ₹60,000 (30 tablets)	1mg
Canada	CAD $850 – $900 (30 tablets)	Canada Pharmacy

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