Brukinsa (Zanubrutinib) 80mg 120 Capsule

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Description

How It Works

Zanubrutinib, the active ingredient in Brukinsa, works by binding to and inhibiting Bruton’s tyrosine kinase (BTK), an enzyme that plays a crucial role in the survival and proliferation of B-cells. By inhibiting BTK, Brukinsa disrupts the signaling pathways necessary for the growth and survival of malignant B-cells, thereby slowing the progression of the disease.

Side Effects

  • Neutropenia (low white blood cell count)
  • Upper respiratory tract infection
  • Bruising
  • Rash
  • Anemia (low red blood cell count)
  • Thrombocytopenia (low platelet count)
  • Muscle pain
  • Fatigue

Indications

  • Mantle cell lymphoma (MCL) in patients who have received at least one prior therapy
  • Chronic lymphocytic leukemia (CLL)
  • Waldenstr?m’s macroglobulinemia (WM)

Contraindications

  • Hypersensitivity to zanubrutinib or any of its components
  • Severe hepatic impairment
  • Concomitant use with strong CYP3A inhibitors

Price Comparison in Different Countries

Country Price (per bottle of 120 capsules) Reference
Pakistan Approximately PKR 1,000,000 Dawaai Pakistan
United States USD 12,000 GoodRx
United Kingdom GBP 9,000 NHS UK
Canada CAD 15,000 Health Canada
Australia AUD 18,000 PBS Australia

Top 5 Global Brands

  1. Roche
  2. Novartis
  3. Pfizer
  4. Merck & Co.
  5. Johnson & Johnson

Conclusion

Brukinsa (Zanubrutinib) 80mg is a critical medication for treating specific blood cancers, including mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenstr?m’s macroglobulinemia. By inhibiting the BTK enzyme, it disrupts the growth and survival of malignant B-cells, providing a targeted treatment option for patients. While effective, Brukinsa does come with potential side effects and contraindications that need careful consideration and management. The cost of Brukinsa varies significantly worldwide, highlighting the importance of accessibility and affordability in cancer treatment. Patients should consult their healthcare providers to determine if Brukinsa is suitable for their condition and explore financial assistance options if necessary.  
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