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  • Bylvay (odevixibat) 1200mcg 30 Capsule

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    Description

    Bylvay, containing the active ingredient odevixibat, is a prescription medication used to treat pruritus (itching) associated with progressive familial intrahepatic cholestasis (PFIC), a rare genetic liver disease. Bylvay works by inhibiting bile acid transport to reduce bile acid levels in the liver, providing relief from symptoms and improving liver function. It is available in capsule form for oral use, typically prescribed for pediatric and adult patients suffering from PFIC.

    How Bylvay Works

    Bylvay (odevixibat) is a reversible inhibitor of the ileal bile acid transporter (IBAT). IBAT plays a crucial role in the enterohepatic circulation of bile acids by transporting bile acids from the intestine back to the liver. By inhibiting IBAT, odevixibat reduces the reabsorption of bile acids in the intestine, leading to a decrease in bile acid levels in the liver and blood. This helps reduce liver damage, inflammation, and the severe itching associated with cholestatic liver diseases such as PFIC.

    Indications

    Bylvay is indicated for the treatment of:
    • Pruritus (itching) associated with progressive familial intrahepatic cholestasis (PFIC) in patients aged 3 months and older.
    • Used in managing symptoms of other cholestatic liver diseases where bile acid buildup causes severe symptoms.

    Side Effects

    Common side effects of Bylvay may include:
    • Diarrhea
    • Abdominal pain
    • Fatigue
    • Nausea
    • Headache
    • Vomiting
    • Increased liver enzyme levels (transaminases)
    Serious side effects may include:
    • Severe diarrhea or dehydration
    • Jaundice (yellowing of skin or eyes)
    • Liver injury or worsening of liver function
    • Severe abdominal pain

    Contraindications

    Bylvay is contraindicated in the following conditions:
    • Complete biliary obstruction: Bylvay should not be used in patients with complete biliary obstruction, as it may worsen the condition.
    • Hypersensitivity: Known hypersensitivity to odevixibat or any of the inactive ingredients in Bylvay.
    • Severe dehydration: Use of Bylvay may exacerbate dehydration caused by diarrhea or vomiting.

    Price of Bylvay in Different Countries

    The price of Bylvay can vary across different regions. Below is a table outlining pricing information in various countries, along with references to reliable sources where the prices can be verified.
    Country Price (per 30 capsules) Source
    United States $10,000 – $12,000 for 30 capsules GoodRx
    United Kingdom £8,000 – £10,000 for 30 capsules NHS UK
    Canada CAD 13,000 – CAD 15,000 for 30 capsules DrugBank Canada
    Australia AUD 18,000 – AUD 20,000 for 30 capsules PBS Australia
    Germany €9,000 – €11,000 for 30 capsules Medikamentenpreis Germany

    Top 5 Global Brands for Treatment of Cholestatic Liver Diseases

    • Bylvay (Odevixibat) – Manufactured by Albireo Pharma, Bylvay is widely used for treating pruritus associated with PFIC.
    • Urso (Ursodiol) – Commonly prescribed for cholestatic liver diseases, it is used to improve bile flow and reduce bile acid buildup.
    • Livodex (Ursodeoxycholic Acid) – Another ursodiol-based treatment for reducing liver damage in cholestatic conditions.
    • Ocaliva (Obeticholic Acid) – Used in the treatment of primary biliary cholangitis (PBC) by regulating bile acid levels in the liver.
    • Cholbam (Cholic Acid) – Indicated for bile acid synthesis disorders and associated liver complications.
     
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    Bylvay (odevixibat) 1200mcg 30 Capsule
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