Cabenuva (cabotegravir + rilpivirine)
Condition : New
0
From UAE
To Pakistan
in 5-10 days
Description
Cabenuva is an injectable treatment for HIV-1 infection that combines two antiretroviral drugs, cabotegravir and rilpivirine. It is designed to be administered monthly or every two months as an alternative to daily oral medications, helping to improve adherence and reduce the treatment burden for people living with HIV.
How Cabenuva Works
Cabenuva combines two active ingredients: cabotegravir and rilpivirine. Cabotegravir is an integrase strand transfer inhibitor (INSTI), which works by blocking the integrase enzyme HIV needs to insert its viral DNA into human cells. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits reverse transcriptase, another enzyme critical to HIV replication. Together, these drugs reduce the HIV viral load by preventing the virus from copying itself and integrating into the host DNA, helping to maintain viral suppression.Indications
Cabenuva is indicated for:- Treatment of HIV-1 infection in adults who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen.
- Patients without a history of treatment failure.
- Individuals without resistance to cabotegravir or rilpivirine.
Side Effects
Common side effects of Cabenuva include:- Injection site reactions (pain, swelling, redness)
- Fever
- Fatigue
- Headache
- Nausea
- Diarrhea
- Hypersensitivity reactions (rash, fever, liver issues)
- Depression or mood changes
- Liver enzyme elevation
Contraindications
Cabenuva should not be used in the following cases:- Allergy: Patients with known hypersensitivity to cabotegravir, rilpivirine, or any components of Cabenuva.
- Concomitant use with certain drugs: Contraindicated with drugs that strongly induce CYP3A or UGT1A1 enzymes, as they may reduce the effectiveness of Cabenuva.
- Liver disease: Use with caution in patients with significant liver impairment, as rilpivirine can worsen hepatic conditions.
Price of Cabenuva in Different Countries
The table below shows approximate pricing for Cabenuva in various countries. Prices may vary depending on insurance, pharmacy, and local regulations.Country | Price (per dose) | Source |
---|---|---|
United States | $3,800 – $4,200 | GoodRx |
Canada | CAD 4,500 – CAD 5,000 | DrugBank Canada |
United Kingdom | £2,900 – £3,500 | NHS UK |
Australia | AUD 5,000 – AUD 5,500 | PBS Australia |
Germany | €3,500 – €4,000 | Medikamentenpreis Germany |
Top 5 Global Brands for HIV Treatment
- Cabenuva (cabotegravir + rilpivirine) – Injectable treatment offering monthly dosing for HIV management.
- Biktarvy (bictegravir, emtricitabine, and tenofovir alafenamide) – Known for high efficacy and once-daily oral dosing.
- Genvoya (elvitegravir, cobicistat, emtricitabine, and tenofovir) – A combination pill simplifying daily treatment.
- Truvada (emtricitabine and tenofovir) – Widely used for PrEP and treatment of HIV.
- Juluca (dolutegravir and rilpivirine) – Two-drug regimen for HIV patients who are already virologically suppressed.
Related products
-
Uncategorized
Uralyt-U Exporter in Dubai, UAE | Best Price | Express Shipping | Long Expiry
Rated 0 out of 5Get Price