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  • Cabenuva (cabotegravir + rilpivirine)

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    Description

    Cabenuva is an injectable treatment for HIV-1 infection that combines two antiretroviral drugs, cabotegravir and rilpivirine. It is designed to be administered monthly or every two months as an alternative to daily oral medications, helping to improve adherence and reduce the treatment burden for people living with HIV.

    How Cabenuva Works

    Cabenuva combines two active ingredients: cabotegravir and rilpivirine. Cabotegravir is an integrase strand transfer inhibitor (INSTI), which works by blocking the integrase enzyme HIV needs to insert its viral DNA into human cells. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits reverse transcriptase, another enzyme critical to HIV replication. Together, these drugs reduce the HIV viral load by preventing the virus from copying itself and integrating into the host DNA, helping to maintain viral suppression.

    Indications

    Cabenuva is indicated for:
    • Treatment of HIV-1 infection in adults who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen.
    • Patients without a history of treatment failure.
    • Individuals without resistance to cabotegravir or rilpivirine.

    Side Effects

    Common side effects of Cabenuva include:
    • Injection site reactions (pain, swelling, redness)
    • Fever
    • Fatigue
    • Headache
    • Nausea
    • Diarrhea
    More severe side effects may include:
    • Hypersensitivity reactions (rash, fever, liver issues)
    • Depression or mood changes
    • Liver enzyme elevation

    Contraindications

    Cabenuva should not be used in the following cases:
    • Allergy: Patients with known hypersensitivity to cabotegravir, rilpivirine, or any components of Cabenuva.
    • Concomitant use with certain drugs: Contraindicated with drugs that strongly induce CYP3A or UGT1A1 enzymes, as they may reduce the effectiveness of Cabenuva.
    • Liver disease: Use with caution in patients with significant liver impairment, as rilpivirine can worsen hepatic conditions.

    Price of Cabenuva in Different Countries

    The table below shows approximate pricing for Cabenuva in various countries. Prices may vary depending on insurance, pharmacy, and local regulations.
    Country Price (per dose) Source
    United States $3,800 – $4,200 GoodRx
    Canada CAD 4,500 – CAD 5,000 DrugBank Canada
    United Kingdom £2,900 – £3,500 NHS UK
    Australia AUD 5,000 – AUD 5,500 PBS Australia
    Germany €3,500 – €4,000 Medikamentenpreis Germany

    Top 5 Global Brands for HIV Treatment

    • Cabenuva (cabotegravir + rilpivirine) – Injectable treatment offering monthly dosing for HIV management.
    • Biktarvy (bictegravir, emtricitabine, and tenofovir alafenamide) – Known for high efficacy and once-daily oral dosing.
    • Genvoya (elvitegravir, cobicistat, emtricitabine, and tenofovir) – A combination pill simplifying daily treatment.
    • Truvada (emtricitabine and tenofovir) – Widely used for PrEP and treatment of HIV.
    • Juluca (dolutegravir and rilpivirine) – Two-drug regimen for HIV patients who are already virologically suppressed.
     
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