Calquence (Acalabrutinib) 100 mg Capsule

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Description

How It Works

Calquence works by inhibiting Bruton’s tyrosine kinase (BTK), an enzyme that plays a crucial role in the survival and proliferation of B-cells. By blocking BTK, Calquence prevents the activation of B-cells, which are often abnormal in blood cancers like MCL and CLL. This inhibition leads to the death of these cancerous cells and reduces their proliferation, thereby controlling the progression of the disease.

Side Effects

  • Headache
  • Diarrhea
  • Fatigue
  • Muscle pain
  • Bruising
  • Infections
  • Anemia
  • Thrombocytopenia
  • Neutropenia
  • Upper respiratory tract infections

Indications

  • Mantle cell lymphoma (MCL) in patients who have received at least one prior therapy
  • Chronic lymphocytic leukemia (CLL)

Contraindications

  • Hypersensitivity to acalabrutinib or any of the excipients
  • Severe hepatic impairment
  • Concurrent use of strong CYP3A inhibitors or inducers

Price Comparison in Different Countries

Country Price (per bottle of 60 capsules) Reference
Pakistan Approximately PKR 800,000 Dawaai Pakistan
United States USD 14,000 GoodRx
United Kingdom GBP 11,000 NHS UK
Canada CAD 18,000 MedBroadcast Canada
Australia AUD 20,000 PBS Australia

Top 5 Global Brands

  1. AstraZeneca
  2. Novartis
  3. Pfizer
  4. Roche
  5. Johnson & Johnson

Conclusion

Calquence (Acalabrutinib) 100 mg capsules offer a vital treatment option for patients with mantle cell lymphoma and chronic lymphocytic leukemia. By targeting and inhibiting Bruton’s tyrosine kinase, it helps manage these types of blood cancers effectively. However, it comes with a range of potential side effects and contraindications that require careful consideration and management by healthcare professionals. The cost of Calquence varies significantly across different countries, highlighting the global disparities in access to cancer treatments. Patients should consult with their healthcare provider to determine if Calquence is the appropriate treatment for their condition and explore possible financial assistance options if needed.  
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