Cialis 20mg film-coated tablets

Cialis is a prescription medication used to treat erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). The active ingredient in Cialis is tadalafil, which belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. It is commonly prescribed to help men achieve and maintain an erection sufficient for sexual activity and to relieve symptoms associated with an enlarged prostate.

How It Works

Cialis works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is involved in the regulation of blood flow in the penis and the prostate. By blocking PDE5, Cialis increases the levels of cyclic guanosine monophosphate (cGMP), a molecule that promotes relaxation of the smooth muscles and dilation of blood vessels. This action enhances blood flow to the penis, facilitating an erection when sexually stimulated. For BPH, Cialis helps relax the muscles in the prostate and bladder, improving urinary symptoms.

Mechanism of Action:

1. PDE5 Inhibition: Cialis selectively inhibits PDE5, leading to increased levels of cGMP.
2. Increased Blood Flow: Enhanced cGMP levels result in the relaxation of smooth muscle in the blood vessels of the penis, allowing increased blood flow and an erection.
3. Prostate Relaxation: In cases of BPH, Cialis helps relax smooth muscles in the prostate and bladder, improving urinary flow and reducing symptoms.

Side Effects

Like all medications, Cialis can cause side effects. While many individuals experience minimal issues, some may experience more significant adverse effects.

Common Side Effects:

• Headache: A frequent side effect that can be bothersome.
• Indigestion: Also known as dyspepsia, can cause discomfort in the stomach area.
• Back Pain: Musculoskeletal pain, particularly in the lower back.
• Muscle Aches: General muscle discomfort or pain.
• Flushing: Redness or warmth of the skin, typically in the face.

Serious Side Effects:

• Prolonged Erection: An erection lasting more than 4 hours (priapism), which requires immediate medical attention.
• Severe Allergic Reactions: Symptoms include rash, itching, swelling, severe dizziness, and trouble breathing.
• Sudden Vision Loss: Rare but serious, possibly indicating a condition known as non-arteritic anterior ischemic optic neuropathy (NAION).
• Sudden Hearing Loss: A rare side effect that may be accompanied by ringing in the ears or dizziness.

Indications

Cialis is primarily indicated for two conditions:

Approved Indications:

1. Erectile Dysfunction (ED): Cialis is used to treat ED, allowing men to achieve and maintain an erection sufficient for sexual activity.
2. Benign Prostatic Hyperplasia (BPH): It is also used to treat BPH symptoms such as urinary urgency, frequency, and discomfort.

Contraindications

Certain conditions and medications may contraindicate the use of Cialis due to potential interactions or adverse effects.

Contraindications:

1. Allergy to Tadalafil: Individuals with known hypersensitivity to tadalafil or any of the components in Cialis should not use this medication.
2. Nitrates Use: Cialis should not be used in combination with nitrates (e.g., nitroglycerin) due to the risk of severe hypotension (low blood pressure).
3. Severe Liver Impairment: Patients with severe liver problems may have altered drug metabolism and should avoid using Cialis.
4. Severe Kidney Disease: Caution is advised in patients with severe kidney impairment as the drug may accumulate in the body.

Price in Different Countries

The cost of Cialis 20 mg Film-Coated Tablets varies by country and is subject to local regulations and pricing structures. Below is a table showing approximate prices in different countries, along with references for further information.

Country	Price (Per Tablet)	Reference
United States	$70 – $80	GoodRx
United Kingdom	£50 – £60	NHS
Australia	AUD $100 – $120	PBS Australia
India	INR ₹4,000 – ₹5,000	1MG
Canada	CAD $90 – $110	Canada Pharmacy