Cycloserine Capsules (Cyclorin)

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Description

How it Works

Cycloserine, marketed under the brand name Cyclorin, is an antibiotic used to treat tuberculosis (TB) and certain other bacterial infections. It works by inhibiting cell wall synthesis in bacteria. Specifically, cycloserine targets and inhibits two enzymes, alanine racemase and D-alanine:D-alanine ligase, which are essential for the production of the bacterial cell wall. By blocking these enzymes, cycloserine prevents bacteria from forming a functional cell wall, which leads to bacterial cell death and helps to control the infection.

Side Effects

  • Headache
  • Dizziness
  • Drowsiness
  • Irritability
  • Depression
  • Tremor
  • Confusion
  • Seizures
  • Peripheral neuropathy
  • Skin rash

Indications

  • Active pulmonary and extrapulmonary tuberculosis
  • Infections caused by Mycobacterium avium complex (MAC)
  • Infections caused by other susceptible mycobacterial species

Contraindications

  • Hypersensitivity to cycloserine or any of its components
  • Epilepsy
  • Severe anxiety or psychosis
  • Severe renal impairment
  • Chronic alcohol use

Price Comparison in Different Countries

Country Price (USD) Website
United States $1,200 GoodRx
Canada $900 PharmacyChecker
United Kingdom ?700 NHS
Australia AUD 1,500 PBS
India ?45,000 Medindia

Top 5 Global Brands

  1. Roche
  2. Pfizer
  3. Novartis
  4. Merck & Co.
  5. Johnson & Johnson
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