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DARZALEX (daratumumab) is a medication used to treat multiple myeloma, a type of cancer that affects plasma cells in the bone marrow. It works by targeting a protein called CD38, which is found at high levels on the surface of myeloma cells. Mechanism of Action: DARZALEX works through several mechanisms:
  • By binding to CD38 on the surface of myeloma cells, DARZALEX triggers immune-mediated destruction of these cells by activating the body’s immune system, including natural killer (NK) cells and macrophages.
  • DARZALEX also directly induces programmed cell death (apoptosis) in myeloma cells.
  • Additionally, DARZALEX may help to inhibit the growth of new blood vessels that supply nutrients to myeloma cells, thereby further slowing tumor growth.
Benefits: The benefits of DARZALEX include:
  • Treatment of multiple myeloma in various settings, including newly diagnosed patients, those who have received prior treatments, and as maintenance therapy after autologous stem cell transplantation.
  • Improvement in overall response rates, progression-free survival, and overall survival in clinical trials.
  • Reduction in symptoms and complications associated with multiple myeloma, such as bone pain, anemia, and kidney dysfunction.
Dosage and Administration: DARZALEX is administered intravenously (into a vein) as an infusion. The recommended dosage and administration schedule may vary depending on the specific treatment regimen and patient characteristics. Healthcare professionals typically determine the appropriate dose and infusion schedule based on factors such as the patient’s weight, medical history, and treatment response. Suitability: DARZALEX is indicated for the treatment of multiple myeloma and is typically prescribed by hematologists or oncologists. The suitability of DARZALEX for an individual patient is determined based on factors such as disease stage, prior treatments received, overall health status, and any underlying medical conditions. Availability: DARZALEX is available by prescription only and is administered in medical facilities equipped to administer intravenous medications, such as hospitals, infusion centers, or outpatient clinics. As for the prices of DARZALEX 400 MG/20 ML INFUZYONLUK COZEL in different countries, specific pricing information would need to be obtained from pharmaceutical databases, local pharmacies, or healthcare providers in those regions.
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