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  • Decapeptyl SR 11.25mg (triptorelin pamoate)

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    Description

    Decapeptyl SR 11.25mg is a formulation of triptorelin pamoate, a synthetic analogue of gonadotropin-releasing hormone (GnRH). It is primarily used in the treatment of hormone-sensitive cancers and other conditions influenced by sex hormones. The medication is administered as an intramuscular injection, providing a slow-release effect that helps in managing hormone levels over a three-month period.

    How It Works

    Triptorelin works by initially stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a temporary increase in sex hormone levels (estrogen and testosterone). However, with continued use, triptorelin desensitizes the pituitary gland, resulting in decreased production of LH and FSH. This ultimately leads to reduced levels of sex hormones, creating a “medical castration” effect. This mechanism is beneficial in treating conditions like prostate cancer, where reduced testosterone levels can slow the growth of cancer cells.

    Side Effects

    Like all medications, Decapeptyl SR 11.25mg may cause side effects. Common side effects include:
    • Hot flashes
    • Fatigue
    • Headache
    • Decreased libido
    • Increased sweating
    • Mood changes
    • Nausea
    Less common but more serious side effects include:
    • Bone density loss
    • Cardiovascular issues (e.g., hypertension, myocardial infarction)
    • Allergic reactions (e.g., rash, itching, difficulty breathing)
    • Urinary tract problems
    • Temporary increase in tumor size (“flare reaction”)

    Indications

    Decapeptyl SR 11.25mg is indicated for:
    • Treatment of advanced prostate cancer
    • Management of endometriosis
    • Uterine fibroids
    • Precocious puberty in children
    • Part of fertility treatment (to control hormonal cycle)

    Contraindications

    Decapeptyl SR 11.25mg should not be used in the following situations:
    • Known hypersensitivity to triptorelin or any of its components
    • Pregnancy and breastfeeding
    • Severe osteoporosis

    Price in Different Countries

    Country Price (per 11.25mg Injection) References
    United States $1,200 GoodRx Decapeptyl Price
    United Kingdom £750 NHS Decapeptyl Price
    Canada $1,000 Pharmacy Checker Decapeptyl Price
    Australia $1,100 PBS Decapeptyl Price
    India ₹85,000 1mg Decapeptyl Price

    Top 5 Global Brands

    The top five global brands for Triptorelin Pamoate include:
    • Decapeptyl (Ipsen Pharmaceuticals): Known for its extensive use in treating hormone-related disorders, Decapeptyl is the leading brand for triptorelin pamoate.
    • Trelstar (Pfizer): A widely recognized brand, offering similar therapeutic benefits for prostate cancer and other hormonal treatments.
    • Salvacyl (Ferring Pharmaceuticals): Another trusted brand, providing effective treatment for various conditions involving hormonal management.
    • Gonapeptyl (Ferring Pharmaceuticals): Offers both daily and long-acting formulations for different medical needs, including fertility treatments.
    • Variopeptyl (Swiss Pharmaceuticals): Known for its affordability and efficacy in international markets, particularly in Europe.
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    Decapeptyl SR 11.25mg (triptorelin pamoate)
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