Dexilant (Dexlansoprazol) 30mg 28 Capsule

Dexilant, with the active ingredient dexlansoprazole, is a proton pump inhibitor (PPI) used primarily to treat conditions related to excessive stomach acid production, such as gastroesophageal reflux disease (GERD) and erosive esophagitis. It is available in 30mg capsules designed for delayed release to provide extended relief from acid-related symptoms.

How It Works

Dexilant (dexlansoprazole) works by inhibiting the proton pump in the gastric parietal cells, effectively reducing gastric acid secretion. Here’s a detailed look at how it functions:

1. Proton Pump Inhibition:
   • Targeting Gastric Parietal Cells: Dexlansoprazole specifically inhibits the H+/K+ ATPase enzyme system, known as the proton pump, in the stomach lining’s parietal cells.
   • Acid Suppression: By blocking this proton pump, Dexilant decreases the amount of acid produced in the stomach, providing relief from symptoms of acid-related disorders.
2. Dual Delayed-Release Technology:
   • Extended Release: Dexilant utilizes a unique dual delayed-release (DDR) formulation that releases the medication in two phases. This allows for a more sustained and prolonged acid suppression, providing relief throughout the day and night.
   • Phase One: The first release occurs within 1-2 hours after ingestion, providing an initial reduction in acid production.
   • Phase Two: The second release occurs approximately 4-5 hours later, maintaining acid suppression for up to 24 hours.
3. Improved Healing and Symptom Relief:
   • Erosive Esophagitis Healing: Dexilant’s acid suppression promotes healing of erosive esophagitis by reducing acid exposure to the esophagus.
   • Symptom Control: It effectively controls symptoms such as heartburn, regurgitation, and dyspepsia associated with GERD and other acid-related disorders.

Clinical Efficacy

Clinical studies have demonstrated that Dexilant is highly effective in reducing gastric acid secretion, healing erosive esophagitis, and providing long-lasting symptom relief for patients with GERD and related conditions. Its DDR formulation offers a distinct advantage in maintaining consistent acid suppression over 24 hours.

Side Effects

While Dexilant is generally well-tolerated, some patients may experience side effects. It is important for patients to be aware of potential adverse reactions and to consult their healthcare provider if they experience any concerning symptoms.

Common Side Effects

• Headache: Mild to moderate headaches are commonly reported.
• Diarrhea: Gastrointestinal disturbances such as diarrhea may occur.
• Nausea: Some patients may experience nausea or stomach discomfort.
• Abdominal Pain: Mild abdominal pain or cramping is possible.
• Flatulence: Increased gas and bloating can occur.
• Dizziness: Some individuals may experience lightheadedness or dizziness.

Serious Side Effects

• Hypomagnesemia: Prolonged use can lead to low magnesium levels, causing symptoms like muscle cramps, seizures, and irregular heartbeats.
• Clostridium Difficile Infection: There is an increased risk of gastrointestinal infections, particularly C. difficile-associated diarrhea.
• Bone Fractures: Long-term use may increase the risk of bone fractures, particularly in the hip, wrist, or spine.
• Vitamin B12 Deficiency: Extended use can lead to vitamin B12 deficiency, potentially causing anemia and neurological issues.
• Allergic Reactions: Severe allergic reactions, including rash, swelling, and difficulty breathing, require immediate medical attention.

Patients experiencing serious side effects should seek medical assistance promptly.

Indications

Dexilant is indicated for the treatment and management of several acid-related gastrointestinal conditions. It provides effective relief from symptoms and promotes healing in affected individuals.

Approved Indications

1. Gastroesophageal Reflux Disease (GERD):
   • Symptomatic GERD: Dexilant is used for the treatment of heartburn associated with symptomatic non-erosive GERD.
   • Erosive Esophagitis: It is indicated for the healing of all grades of erosive esophagitis and maintenance of healed erosive esophagitis.
2. Zollinger-Ellison Syndrome:
   • Dexilant is used to manage pathological hypersecretory conditions like Zollinger-Ellison syndrome, where excessive stomach acid production occurs.
3. Peptic Ulcers:
   • While not its primary indication, Dexilant can aid in the treatment of gastric and duodenal ulcers by reducing acid secretion.

Contraindications

1. Hypersensitivity:
   • Patients with known hypersensitivity to dexlansoprazole, lansoprazole, or any other components of Dexilant should not use this medication due to the risk of severe allergic reactions.
2. Rilpivirine Use:
   • Concomitant use with rilpivirine-containing products is contraindicated, as it may reduce the effectiveness of rilpivirine, used to treat HIV infection.
3. Severe Liver Impairment:
   • Patients with severe hepatic impairment should use Dexilant cautiously, as it is primarily metabolized by the liver.
4. Pregnancy and Lactation:
   • Dexilant should be used during pregnancy only if clearly needed, and breastfeeding is not recommended as it may pass into breast milk.

Price in Different Countries

The cost of Dexilant can vary based on country, healthcare system, and insurance coverage. Below is a table providing an overview of the approximate price of Dexilant in various countries.

Country	Price (USD) Per 30mg Capsule	Reference Link
United States	$8 – $10	GoodRx
Canada	$4 – $6	CanadaDrugs
United Kingdom	£3 – £5	NHS
Australia	$5 – $7	PBS
Germany	€4 – €6	Apotheken Umschau

Top 5 Global Brands

Several global pharmaceutical companies are known for their innovative contributions to gastrointestinal treatments and proton pump inhibitors like Dexilant. Here are the top 5 global brands:

1. Takeda Pharmaceutical Company Limited:
   • The developer of Dexilant, Takeda is a leading global pharmaceutical company focused on gastroenterology, oncology, and neuroscience.
2. AstraZeneca PLC:
   • Known for its extensive portfolio of gastrointestinal treatments, including proton pump inhibitors like Nexium.
3. Pfizer Inc.:
   • A major player in the pharmaceutical industry, offering a range of gastrointestinal and digestive health products.
4. Bayer AG:
   • Renowned for its innovative treatments for gastrointestinal disorders and other therapeutic areas.
5. Johnson & Johnson:
   • A global healthcare leader providing a wide range of products for digestive health and gastroenterology.

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