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  • Dificlir (Fidaxomicin) 200mg Tablet

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    Description

    Dificlir, also known by its generic name Fidaxomicin, is an antibiotic medication used primarily to treat Clostridium difficile infections (CDI). It is available in 200mg tablet form and is taken orally. Fidaxomicin works by inhibiting bacterial RNA synthesis, thereby preventing the bacteria from replicating and spreading. It is particularly effective against C. difficile, which is known to cause severe diarrhea and colitis.

    How It Works

    Fidaxomicin targets the bacterial enzyme RNA polymerase, which is essential for RNA synthesis. By binding to this enzyme, Fidaxomicin inhibits the production of RNA, thus halting protein synthesis and bacterial replication. This mechanism is highly specific to C. difficile, making Fidaxomicin effective at treating infections caused by this bacterium while having minimal impact on the beneficial bacteria in the gut.

    Side Effects

    • Nausea
    • Vomiting
    • Abdominal pain
    • Diarrhea
    • Flatulence
    • Headache
    • Constipation
    • Increased liver enzymes
    • Hypersensitivity reactions (rash, itching)

    Indications

    • Treatment of Clostridium difficile infection (CDI) in adults.

    Contraindications

    • Known hypersensitivity to Fidaxomicin or any of its components.
    • Severe liver impairment.
    • Concurrent use with other medications that may interact adversely with Fidaxomicin.

    Price in Different Countries

    Country Price (per 200mg tablet) References
    United States $450 GoodRx Dificlir Price
    United Kingdom £350 NHS Dificlir Price
    Canada $400 Canada Drugs Dificlir Price
    Australia $420 PBS Dificlir Price
    India ₹30,000 1mg Dificlir Price

    Top 5 Global Brands

    • Dificlir (Astellas Pharma Inc.): The primary and most recognized brand for Fidaxomicin, used in the treatment of C. difficile infection.
    • Vancomycin (Various brands): An alternative antibiotic used for severe C. difficile infections, although with a different mechanism of action.
    • Metronidazole (Various brands): Another alternative antibiotic for mild to moderate C. difficile infections.
    • Flagyl (Pfizer Inc.): A brand of Metronidazole, commonly used for anaerobic bacterial infections including C. difficile.
    • Vancocin (Eli Lilly and Company): A brand of Vancomycin, specifically used for severe cases of C. difficile infection.
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    Dificlir (Fidaxomicin) 200mg Tablet
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