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  • Doptelet 20 mg film-coated tablets

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    Description

    Doptelet (avatrombopag) is a medication available in the form of 20 mg film-coated tablets. It is primarily used to treat thrombocytopenia (low platelet count) in patients with chronic liver disease who are scheduled to undergo a medical or dental procedure. Doptelet works by stimulating the production of platelets in the bone marrow.

    How It Works

    Doptelet contains avatrombopag, a thrombopoietin receptor agonist. It works by mimicking the action of thrombopoietin, a natural hormone that regulates the production of platelets. By binding to thrombopoietin receptors on the surface of megakaryocytes (the cells in the bone marrow that produce platelets), Doptelet stimulates the production and release of platelets into the bloodstream. This increase in platelet count helps to reduce the risk of bleeding and allows for safer medical or dental procedures.

    Side Effects

    • Headache
    • Nausea
    • Diarrhea
    • Fatigue
    • Dizziness
    • Elevated liver enzymes
    • Rash
    • Muscle pain
    • Abdominal pain

    Indications

    • Management of thrombocytopenia in patients with chronic liver disease.
    • Preparation for medical or dental procedures in patients with low platelet counts.

    Contraindications

    • Known hypersensitivity to avatrombopag or any of the components of Doptelet.
    • Severe liver impairment.
    • Active liver disease or liver failure.
    • Current or history of blood clots or thrombotic events, unless carefully monitored by a healthcare provider.

    Price in Different Countries

    Country Price (per 20 mg tablet) References
    United States $300 per tablet GoodRx Doptelet Price
    United Kingdom £250 per tablet NHS Doptelet Price
    Canada $280 per tablet Canada Drugs Doptelet Price
    Australia $320 per tablet PBS Doptelet Price
    India ₹22,000 per tablet 1mg Doptelet Price

    Top 5 Global Brands

    • Doptelet (Dova Pharmaceuticals): The original brand name for avatrombopag, specifically indicated for thrombocytopenia management.
    • Promacta (Novartis): Another thrombopoietin receptor agonist used for treating thrombocytopenia, similar to Doptelet but with different dosing.
    • Revolade (Novartis): Marketed as Promacta in the US, used for similar indications as Doptelet, focusing on increasing platelet counts.
    • Eltrombopag (various generics): A generic version of the active ingredient in Promacta and Revolade, used for treating thrombocytopenia.
    • Neumega (Amgen): Used for increasing platelet counts in patients undergoing chemotherapy, though with a different mechanism than Doptelet.
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    Doptelet 20 mg film-coated tablets
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