Enspryng (Satralizumab) injection 120mg/ml
Enspryng (Satralizumab) injection 120mg/ml
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Description
Enspryng (Satralizumab) is a monoclonal antibody designed for the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune disease that affects the central nervous system. It is available as an injection with a concentration of 120 mg/ml. Enspryng is used to help reduce the frequency of NMOSD relapses by targeting and inhibiting interleukin-6 (IL-6), a cytokine involved in inflammation and disease progression.
How It Works
Enspryng (Satralizumab) is a humanized monoclonal antibody that binds specifically to interleukin-6 (IL-6) receptors. By inhibiting the action of IL-6, which plays a crucial role in the inflammatory response and the progression of autoimmune diseases, Enspryng helps to reduce inflammation and prevent further damage to the central nervous system. This action contributes to a decrease in the frequency and severity of NMOSD relapses.Side Effects
- Headache
- Fatigue
- Nausea
- Injection site reactions (redness, swelling, itching)
- Fever
- Upper respiratory tract infections
- Increased liver enzymes
- Rash
- Joint pain
Indications
- Treatment of neuromyelitis optica spectrum disorder (NMOSD) in adults who are anti-aquaporin-4 (AQP4) antibody positive.
Contraindications
- Known hypersensitivity to Satralizumab or any of its components.
- Active or severe infections that may be exacerbated by immunosuppressive therapies.
- Severe hepatic impairment.
Price in Different Countries
| Country | Price (per 120mg/ml injection) | References |
|---|---|---|
| United States | $4,200 | GoodRx Enspryng Price |
| United Kingdom | £3,200 | NHS Enspryng Price |
| Canada | $3,800 | Canada Drugs Enspryng Price |
| Australia | $4,000 | PBS Enspryng Price |
| India | ₹300,000 | 1mg Enspryng Price |
Top 5 Global Brands
- Enspryng (Genentech/Roche): The primary and most recognized brand for Satralizumab, specifically used for NMOSD.
- Ocrevus (Genentech/Roche): Another brand for multiple sclerosis with similar immunomodulatory effects.
- Soliris (Alexion Pharmaceuticals): Used for rare diseases involving complement system dysregulation.
- Kesimpta (Novartis): A monoclonal antibody used for multiple sclerosis, similar in class but with different indications.
- Actemra (Roche): An IL-6 receptor inhibitor used for rheumatoid arthritis and other inflammatory conditions.