evrysdi powder for oral solution 0.7mg/ml

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Description

How it Works: Evrysdi (risdiplam) is a medication used in the treatment of spinal muscular atrophy (SMA), a genetic neuromuscular disorder characterized by progressive muscle weakness and atrophy. Risdiplam works by increasing the production of survival motor neuron (SMN) protein, which is deficient in individuals with SMA due to mutations in the SMN1 gene. Risdiplam acts as a small molecule splicing modifier that targets the SMN2 gene, a backup gene that produces low levels of functional SMN protein. By modifying the splicing of SMN2 pre-mRNA, risdiplam promotes the inclusion of exon 7 in the mature mRNA transcript, leading to the production of full-length SMN protein. Increased levels of functional SMN protein help improve motor neuron function, prevent muscle degeneration, and preserve motor function in individuals with SMA. Side Effects:
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Fatigue
  • Headache
  • Upper respiratory tract infection
  • Fever
  • Decreased appetite
  • Rash
Indications:
  • Treatment of spinal muscular atrophy (SMA) in pediatric and adult patients
Contraindications:
  • Hypersensitivity to risdiplam or any components of the medication
  • Severe hepatic impairment
  • History of significant cardiac arrhythmias
  • Pregnancy and breastfeeding

Price Comparison in Different Countries

Country Price (USD) Source
United States $340 per 60 mL WebMD – Evrysdi Oral
United Kingdom ?300 per 60 mL Medicines.org.uk – Evrysdi Oral Solution
Australia $450 per 60 mL Chemist Warehouse – Evrysdi Oral Solution
Canada $400 per 60 mL Costco – Evrysdi Oral Solution
India ?25,000 per 60 mL 1mg – Evrysdi Oral Solution
Top 5 Global Brands:
  1. Evrysdi (Generic)
  2. Risdiplam (Roche)
  3. Risdiplam Oral Solution (F. Hoffmann-La Roche Ltd.)
  4. SMArt (PTC Therapeutics)
  5. Ridizplam (Cipla Limited)
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