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FABRAZYME (agalsidase beta) is a medication used to treat Fabry disease, a rare genetic disorder characterized by the deficiency of an enzyme called alpha-galactosidase A. Here’s an overview: Pros:
  1. Enzyme Replacement Therapy (ERT): FABRAZYME is a form of ERT, which works by replacing the missing or deficient enzyme in individuals with Fabry disease. By providing the enzyme, FABRAZYME helps to break down a certain type of fat that accumulates in the body due to the enzyme deficiency.
  2. Symptom Management: Treatment with FABRAZYME can help alleviate symptoms associated with Fabry disease, including pain, kidney dysfunction, heart problems, and skin manifestations.
  3. Improvement in Quality of Life: Clinical studies have shown that FABRAZYME treatment can lead to improvements in quality of life for patients with Fabry disease, reducing pain and other symptoms associated with the condition.
  4. Long-Term Management: FABRAZYME is typically administered intravenously every two weeks, providing continuous enzyme replacement therapy for patients with Fabry disease.
  1. Cost: FABRAZYME can be expensive, especially for those without adequate insurance coverage. The price can vary depending on factors such as location and insurance plan.
  2. Infusion-Related Reactions: Some patients may experience infusion-related reactions, such as fever, chills, headache, and allergic reactions, during or after receiving FABRAZYME infusions. These reactions are usually mild to moderate but may require medical intervention in some cases.
  3. Development of Antibodies: In some patients, the immune system may produce antibodies against FABRAZYME, which can reduce its effectiveness over time. Close monitoring is necessary to detect the development of antibodies and adjust treatment if needed.
Price Comparison: The price of FABRAZYME 35 mg per vial can vary significantly depending on the country, pharmacy, and insurance coverage. In the United States, for example, the average wholesale price (AWP) for FABRAZYME can range from $5,000 to $7,000 per vial. However, patients may be eligible for financial assistance programs from the manufacturer or other sources to help cover the cost. Patients should discuss the potential benefits and risks of FABRAZYME with their healthcare provider, as well as any concerns about affordability. Close monitoring is essential to manage side effects and ensure the best treatment outcomes.
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