Gabasign (Gabapentin) 400 mg Capsules

Gabasign is a brand of gabapentin, a medication primarily used to treat seizures and neuropathic pain. It belongs to a class of drugs known as anticonvulsants and is available in capsule form, with each capsule containing 400 mg of gabapentin.

How It Works

Gabapentin works by mimicking the neurotransmitter gamma-aminobutyric acid (GABA), though it does not bind directly to GABA receptors. Instead, gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action inhibits the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. The reduction in neurotransmitter release leads to decreased neuronal excitability, which helps control seizures and alleviate neuropathic pain.

Indications

Gabapentin is used to treat a variety of medical conditions, including:

• Epilepsy: Used as an adjunctive therapy for partial seizures with or without secondary generalization in adults and children aged 3 years and above.
• Postherpetic Neuralgia: Pain following shingles (herpes zoster) in adults.
• Diabetic Neuropathy: Nerve pain associated with diabetes.
• Fibromyalgia: A condition characterized by widespread musculoskeletal pain.
• Restless Legs Syndrome (RLS): Unpleasant sensations in the legs and an uncontrollable urge to move them.

Side Effects

Common side effects of Gabasign (gabapentin) may include:

• Dizziness
• Drowsiness
• Fatigue
• Coordination problems
• Nausea and vomiting
• Peripheral edema (swelling of the extremities)
• Dry mouth
• Weight gain

Serious side effects that require medical attention include:

• Severe allergic reactions (e.g., rash, itching, swelling, dizziness, trouble breathing)
• Changes in mood or behavior (e.g., depression, anxiety, suicidal thoughts)
• Severe dizziness or fainting
• Unusual bleeding or bruising
• Seizures (if they become more frequent or severe)

Contraindications

Gabapentin should not be used in the following situations:

• Hypersensitivity: Known allergy to gabapentin or any components of the formulation.
• Severe Renal Impairment: Dosage adjustments may be necessary for patients with impaired kidney function, but it is generally contraindicated in severe cases without close medical supervision.
• Pregnancy and Lactation: Should be used only if the potential benefit justifies the potential risk to the fetus or infant.

Pricing Information

Country	Price (per 400 mg Capsule)	Reference
United States	$1.50 – $3.00	GoodRx
Canada	CAD $0.70 – $1.50	DrugBank
United Kingdom	£0.60 – £1.20	NICE
Australia	AUD $0.80 – $1.60	PBS
Germany	€0.50 – €1.00	Apotheken Umschau

This comprehensive overview provides detailed information about Gabasign (Gabapentin) 400 mg Capsules, including its mechanism of action, uses, side effects, contraindications, pricing information, and leading brands in the global market.