Gilenya (Fingolimod) 0.5 mg Capsules

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Description

How It Works

Gilenya works by modulating the activity of sphingosine 1-phosphate (S1P) receptors. Fingolimod, the active ingredient, is phosphorylated to form fingolimod-phosphate, which binds to S1P receptors on the surface of lymphocytes (a type of white blood cell). This binding sequesters lymphocytes in lymph nodes, preventing them from circulating in the central nervous system (CNS) and causing inflammatory damage to the nerves. By reducing lymphocyte migration into the CNS, Gilenya helps decrease the autoimmune attacks that characterize multiple sclerosis.

Side Effects

  • Headache
  • Back pain
  • Diarrhea
  • Cough
  • Flu-like symptoms
  • Elevated liver enzymes
  • Bradycardia (slow heart rate)
  • Hypertension (high blood pressure)
  • Macular edema (swelling in the back of the eye)

Indications

  • Relapsing-remitting multiple sclerosis (RRMS)
  • Active secondary progressive multiple sclerosis (SPMS)
  • Clinically isolated syndrome (CIS) with features suggestive of multiple sclerosis

Contraindications

  • Hypersensitivity to fingolimod or any of its components
  • Recent heart attack or stroke
  • Unstable angina or severe heart failure
  • Certain types of irregular or abnormal heartbeats (arrhythmias)
  • Severe liver impairment
  • Active infections
  • Pregnancy

Price Comparison in Different Countries

Country Price (per capsule) Reference
Pakistan Approximately PKR 3,500 Dawaai Pakistan
United States USD 230 GoodRx
United Kingdom GBP 190 NHS UK
Canada CAD 300 Health Canada
Australia AUD 350 PBS Australia

Top 5 Global Brands

  1. Novartis
  2. Pfizer
  3. Roche
  4. Sanofi
  5. GlaxoSmithKline (GSK)

Conclusion

Gilenya (fingolimod) is a vital medication for managing relapsing forms of multiple sclerosis. By modulating the activity of sphingosine 1-phosphate receptors, Gilenya reduces the autoimmune attacks on the central nervous system, decreasing relapse frequency and slowing disability progression. Patients should be aware of potential side effects and contraindications, and consult their healthcare provider for personalized advice. The cost of Gilenya varies across different countries, reflecting variations in healthcare systems and pricing policies. Exploring financial assistance programs and discussing options with healthcare providers can help manage the cost of treatment effectively.  
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