Hepcinat - Ledipasvir And Sofosbuvir Tablets 90mg / 400mg

How it Works: Hepcinat tablets contain a combination of two direct-acting antiviral agents: Ledipasvir and Sofosbuvir. This combination medication is used in the treatment of chronic hepatitis C virus (HCV) infection. Ledipasvir is an inhibitor of the HCV NS5A protein, while Sofosbuvir is a nucleotide analog inhibitor of the HCV NS5B RNA-dependent RNA polymerase. Ledipasvir interferes with the replication and assembly of the hepatitis C virus by targeting the NS5A protein, which plays a crucial role in viral replication and virion assembly. Sofosbuvir works by inhibiting the NS5B polymerase, an enzyme essential for the replication of HCV RNA. By targeting different steps in the HCV life cycle, the combination of Ledipasvir and Sofosbuvir helps suppress viral replication, reduce viral load, and achieve sustained virologic response (SVR), leading to the cure of chronic hepatitis C infection. Side Effects:

• Fatigue
• Headache
• Nausea
• Insomnia
• Anemia
• Diarrhea
• Decreased appetite
• Abdominal pain
• Weakness
• Rash
• Dizziness

Indications:

• Treatment of chronic hepatitis C virus (HCV) infection

Contraindications:

• Hypersensitivity to Ledipasvir, Sofosbuvir, or any components of the tablets
• Severe renal impairment (eGFR less than 30 mL/min/1.73 m²)
• Concomitant use with strong inducers of cytochrome P450 (CYP) 3A4
• Pregnancy and breastfeeding
• Severe hepatic impairment (Child-Pugh class C)

Price Comparison in Different Countries

Country	Price (USD)	Source
United States	$1,000	WebMD – Hepcinat Tablets
United Kingdom	?800	Medicines.org.uk – Hepcinat Tablets
Australia	$1,200	Chemist Warehouse – Hepcinat Tablets
Canada	$1,100	Costco – Hepcinat Tablets
India	?70,000	1mg – Hepcinat Tablets

Top 5 Global Brands:

1. Hepcinat (Natco Pharma)
2. Harvoni (Gilead Sciences)
3. Sovaldi (Gilead Sciences)
4. Myhep (Mylan Pharmaceuticals)
5. Velpanat (Natco Pharma)