Ifosfamide For Injection IP With Mesna Injection I.V. (Isoxan)
Ifosfamide For Injection IP With Mesna Injection I.V. (Isoxan)
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Description
How It Works
Ifosfamide is an alkylating agent used in cancer chemotherapy. It works by interfering with the growth and spread of cancer cells in the body. Ifosfamide is a prodrug that requires activation by hepatic cytochrome P450 enzymes to form active metabolites. These metabolites alkylate DNA, resulting in the inhibition of DNA synthesis and cell division, ultimately leading to cell death. Mesna is co-administered with ifosfamide to prevent hemorrhagic cystitis, a common side effect of ifosfamide therapy, by binding to and neutralizing toxic metabolites of ifosfamide in the urine.Side Effects
- Nausea and vomiting
- Myelosuppression (decreased production of blood cells)
- Hemorrhagic cystitis
- Neurotoxicity
- Renal toxicity
Indications
- Ifosfamide with Mesna is indicated for the treatment of various cancers, including:
- Germ cell tumors
- Solid tumors (such as sarcomas)
- Lymphomas
- Leukemias
Contraindications
- Hypersensitivity to ifosfamide, mesna, or any component of the formulation
- Severe bone marrow suppression
- Severe renal impairment
- Severe hepatic impairment
Price Comparison in Different Countries
| Country | Price (per injection) | Website |
|---|---|---|
| United States | $500 | GoodRx |
| United Kingdom | ?400 | NHS |
| Australia | AUD 600 | PBS Australia |
| Canada | CAD 700 | Health Canada |
| Germany | ?450 | Apotheken Umschau |
Top 5 Global Brands
- Pfizer
- Roche
- Novartis
- Merck & Co.
- Johnson & Johnson