Ifosfamide For Injection IP With Mesna Injection I.V. (Isoxan)

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Description

How It Works

Ifosfamide is an alkylating agent used in cancer chemotherapy. It works by interfering with the growth and spread of cancer cells in the body. Ifosfamide is a prodrug that requires activation by hepatic cytochrome P450 enzymes to form active metabolites. These metabolites alkylate DNA, resulting in the inhibition of DNA synthesis and cell division, ultimately leading to cell death. Mesna is co-administered with ifosfamide to prevent hemorrhagic cystitis, a common side effect of ifosfamide therapy, by binding to and neutralizing toxic metabolites of ifosfamide in the urine.

Side Effects

  • Nausea and vomiting
  • Myelosuppression (decreased production of blood cells)
  • Hemorrhagic cystitis
  • Neurotoxicity
  • Renal toxicity

Indications

  • Ifosfamide with Mesna is indicated for the treatment of various cancers, including:
    • Germ cell tumors
    • Solid tumors (such as sarcomas)
    • Lymphomas
    • Leukemias

Contraindications

  • Hypersensitivity to ifosfamide, mesna, or any component of the formulation
  • Severe bone marrow suppression
  • Severe renal impairment
  • Severe hepatic impairment

Price Comparison in Different Countries

Country Price (per injection) Website
United States $500 GoodRx
United Kingdom ?400 NHS
Australia AUD 600 PBS Australia
Canada CAD 700 Health Canada
Germany ?450 Apotheken Umschau

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