Imfinzi 120mg/2.4mlDurvalumab injection

How it Works

Imfinzi (durvalumab) is a monoclonal antibody used in cancer immunotherapy. It targets and binds to the programmed death-ligand 1 (PD-L1) protein found on the surface of cancer cells and some immune cells. PD-L1 interacts with the programmed death-1 (PD-1) receptor on T-cells (a type of immune cell), leading to the inhibition of the T-cells? ability to attack cancer cells. By blocking the PD-L1/PD-1 interaction, durvalumab reactivates T-cells, enabling them to recognize and destroy cancer cells. This mechanism of action helps enhance the body’s immune response against tumors, particularly in certain types of cancers.

Side Effects

• Fatigue
• Nausea
• Diarrhea
• Decreased appetite
• Rash
• Constipation
• Arthralgia (joint pain)
• Cough
• Infections
• Shortness of breath
• Abdominal pain
• Fever
• Elevated liver enzymes

Indications

• Unresectable stage III non-small cell lung cancer (NSCLC) that has not progressed following concurrent platinum-based chemotherapy and radiation therapy
• Extensive-stage small cell lung cancer (ES-SCLC) in combination with chemotherapy
• Locally advanced or metastatic urothelial carcinoma in patients who have disease progression during or following platinum-containing chemotherapy

Contraindications

• Hypersensitivity to durvalumab or any of its excipients
• Patients with active or history of autoimmune diseases requiring systemic treatment
• Severe or life-threatening infusion-related reactions
• Severe immune-mediated adverse reactions (e.g., pneumonitis, hepatitis, colitis)
• Pregnancy and breastfeeding (use with caution and only if clearly needed)

Price Comparison in Different Countries

Country	Price (USD)	Website
United States	$9,200	GoodRx
Canada	$7,800	PharmacyChecker
United Kingdom	?6,500	NHS
Australia	AUD 11,000	PBS
India	?700,000	Medindia

Top 5 Global Brands

1. Imfinzi (AstraZeneca)
2. Keytruda (Merck & Co.)
3. Opdivo (Bristol-Myers Squibb)
4. Tecentriq (Genentech/Roche)
5. Bavencio (EMD Serono/Pfizer)