Imfinzi 120mg/2.4mlDurvalumab injection

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Description

How it Works

Imfinzi (durvalumab) is a monoclonal antibody used in cancer immunotherapy. It targets and binds to the programmed death-ligand 1 (PD-L1) protein found on the surface of cancer cells and some immune cells. PD-L1 interacts with the programmed death-1 (PD-1) receptor on T-cells (a type of immune cell), leading to the inhibition of the T-cells? ability to attack cancer cells. By blocking the PD-L1/PD-1 interaction, durvalumab reactivates T-cells, enabling them to recognize and destroy cancer cells. This mechanism of action helps enhance the body’s immune response against tumors, particularly in certain types of cancers.

Side Effects

  • Fatigue
  • Nausea
  • Diarrhea
  • Decreased appetite
  • Rash
  • Constipation
  • Arthralgia (joint pain)
  • Cough
  • Infections
  • Shortness of breath
  • Abdominal pain
  • Fever
  • Elevated liver enzymes

Indications

  • Unresectable stage III non-small cell lung cancer (NSCLC) that has not progressed following concurrent platinum-based chemotherapy and radiation therapy
  • Extensive-stage small cell lung cancer (ES-SCLC) in combination with chemotherapy
  • Locally advanced or metastatic urothelial carcinoma in patients who have disease progression during or following platinum-containing chemotherapy

Contraindications

  • Hypersensitivity to durvalumab or any of its excipients
  • Patients with active or history of autoimmune diseases requiring systemic treatment
  • Severe or life-threatening infusion-related reactions
  • Severe immune-mediated adverse reactions (e.g., pneumonitis, hepatitis, colitis)
  • Pregnancy and breastfeeding (use with caution and only if clearly needed)

Price Comparison in Different Countries

Country Price (USD) Website
United States $9,200 GoodRx
Canada $7,800 PharmacyChecker
United Kingdom ?6,500 NHS
Australia AUD 11,000 PBS
India ?700,000 Medindia

Top 5 Global Brands

  1. Imfinzi (AstraZeneca)
  2. Keytruda (Merck & Co.)
  3. Opdivo (Bristol-Myers Squibb)
  4. Tecentriq (Genentech/Roche)
  5. Bavencio (EMD Serono/Pfizer)
 
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