imnovid 4mg pomalidomida

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Description

How it Works

Imnovid, also known as pomalidomide, is an immunomodulatory agent used primarily in the treatment of multiple myeloma. Pomalidomide works through multiple mechanisms to combat cancer cells. It enhances the immune system by stimulating T-cells and natural killer cells, which attack cancer cells. Additionally, pomalidomide inhibits angiogenesis, the process by which new blood vessels form to supply nutrients to tumors, thereby starving the cancer cells. It also induces apoptosis, or programmed cell death, directly in myeloma cells. The exact mechanism of action involves modulation of the cereblon E3 ubiquitin ligase complex, leading to the degradation of specific transcription factors essential for the survival and proliferation of myeloma cells.

Side Effects

  • Fatigue
  • Anemia (low red blood cell count)
  • Neutropenia (low white blood cell count)
  • Thrombocytopenia (low platelet count)
  • Nausea
  • Constipation
  • Diarrhea
  • Dyspnea (difficulty breathing)
  • Peripheral edema (swelling of extremities)
  • Infections
  • Rash
  • Back pain
  • Fever
  • Neuropathy (nerve damage)

Indications

  • Multiple myeloma in patients who have received at least two prior therapies including lenalidomide and a proteasome inhibitor, and have demonstrated disease progression on or within 60 days of completion of the last therapy.

Contraindications

  • Hypersensitivity to pomalidomide or any of its excipients
  • Pregnancy, due to the risk of severe birth defects or embryo-fetal death
  • Lactating women
  • Severe hepatic impairment

Price Comparison in Different Countries

Country Price (USD) Website
United States $16,000 per month GoodRx
Canada $14,000 per month PharmacyChecker
United Kingdom ?12,000 per month NHS
Australia AUD 20,000 per month PBS
Pakistan PKR 2,500,000 per month DawaTech

Top 5 Global Brands

  1. Imnovid (Celgene)
  2. Revlimid (Celgene)
  3. Thalomid (Celgene)
  4. Velcade (Takeda)
  5. Kyprolis (Amgen)
 
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