JEVTANA 60 MG/1,5 ML 1 FLC

Jevtana (generic name: Cabazitaxel) is an intravenous chemotherapy medication used in the treatment of advanced prostate cancer. It is part of a class of drugs known as taxanes, which work by interfering with the normal function of microtubules during cell division, leading to cancer cell death.

How Jevtana Works

Mechanism of Action

1. Microtubule Stabilization:
   • Cabazitaxel binds to the microtubules, which are essential components of the cell’s cytoskeleton. By stabilizing microtubules, Jevtana disrupts the normal breakdown and reorganization of these structures during cell division.
2. Inhibition of Cell Division:
   • The stabilization of microtubules prevents the normal mitotic spindle formation necessary for cell division. This interference halts the process of cell division and leads to cell death, particularly in rapidly dividing cancer cells.
3. Induction of Apoptosis:
   • By disrupting microtubule dynamics, Jevtana induces apoptosis (programmed cell death) in cancer cells, contributing to the reduction of tumor size and progression.

Side Effects

Common Side Effects

• Nausea and Vomiting:
  • Many patients experience nausea and vomiting, which can often be managed with antiemetic medications.
• Fatigue:
  • Fatigue is a common side effect, and patients may need rest and support to manage this symptom.
• Diarrhea:
  • Diarrhea is frequently reported and can be managed with appropriate medications and dietary changes.
• Loss of Appetite:
  • Reduced appetite may occur, and nutritional support may be required.
• Hair Loss:
  • Temporary hair loss may happen as a result of the drug’s effect on rapidly dividing cells.

Serious Side Effects

• Neutropenia:
  • A significant reduction in white blood cells can lead to increased risk of infections. Regular monitoring of blood counts is necessary.
• Anemia:
  • Decreased red blood cell count may cause symptoms like weakness and shortness of breath.
• Thrombocytopenia:
  • Low platelet counts can increase the risk of bleeding and bruising.
• Severe Allergic Reactions:
  • Rarely, patients may experience severe allergic reactions, including anaphylaxis, which requires immediate medical attention.
• Hepatotoxicity:
  • Liver function abnormalities may occur, necessitating monitoring of liver enzymes.

Indications

Jevtana is indicated for:

• Advanced Prostate Cancer:
  • Used in combination with prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in patients who have previously been treated with a docetaxel-based regimen.

Contraindications

Jevtana should not be used in the following conditions:

• Hypersensitivity:
  • Known hypersensitivity to cabazitaxel or any of its components.
• Severe Liver Impairment:
  • Patients with severe liver dysfunction should avoid Jevtana due to the risk of exacerbating liver issues.
• Severe Bone Marrow Suppression:
  • Patients with severe bone marrow suppression or compromised blood cell counts are contraindicated.
• Pregnancy:
  • Jevtana is contraindicated during pregnancy due to potential harm to the fetus. Effective contraception is advised during treatment.
• Breastfeeding:
  • The use of Jevtana during breastfeeding is not recommended, as it may affect the infant.

Price in Different Countries

The price of Jevtana 60 mg/1.5 ml varies by country and healthcare system. Below is a table showing approximate price ranges in various countries.

Country	Price (Per 1.5 ml)	Reference
United States	$7,000 – $8,500	GoodRx
United Kingdom	£5,800 – £6,500	NHS UK
Canada	CAD $8,500 – $9,500	Health Canada
Australia	AUD $9,500 – $10,500	PBS Australia
India	₹5,50,000 – ₹6,50,000	Medlife

Top 5 Global Brands

1. Jevtana – Sanofi:
   • The original manufacturer of cabazitaxel, known for its quality and effectiveness in treating advanced prostate cancer.
2. Cabazitaxel – Mylan:
   • A leading producer of generic cabazitaxel, providing a cost-effective alternative to Jevtana.
3. Cabazitaxel – Teva:
   • Another major manufacturer of generic cabazitaxel, offering an affordable option for patients.
4. Cabazitaxel – Sandoz:
   • Known for producing high-quality generic cabazitaxel with adherence to rigorous standards.
5. Cabazitaxel – Dr. Reddy’s Laboratories:
   • Provides a reliable generic version of cabazitaxel, ensuring accessibility for patients globally.