krystexxa (pegloticase) injection 8mg/ml


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Krystexxa (pegloticase) is a medication used for the treatment of chronic gout that is refractory to conventional therapy. Each milliliter of solution contains 8 mg of pegloticase, an enzyme that helps to lower uric acid levels in the blood. It is administered via intravenous infusion and works by converting uric acid to allantoin, a more easily excreted substance.

How It Works

Pegloticase is a recombinant, pegylated uricase enzyme. Uricase catalyzes the oxidation of uric acid into allantoin, which is more soluble and can be easily excreted by the kidneys. This enzymatic action significantly reduces the levels of uric acid in the blood, thereby preventing the formation of uric acid crystals that cause gout attacks. Pegloticase is used when conventional treatments such as allopurinol or febuxostat are ineffective or not tolerated by the patient.


  • Chronic gout in adult patients who have not responded to conventional therapy


  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency due to risk of hemolysis and methemoglobinemia
  • Hypersensitivity to pegloticase or any component of the formulation

Side Effects

  • Infusion-related reactions (e.g., headache, nausea, chest pain)
  • Anaphylaxis
  • Gout flares
  • Bruising or irritation at the injection site
  • Nausea
  • Back pain
  • Constipation
  • Chest pain
  • Vomiting
  • Nasopharyngitis

Price in Different Countries

Country Price (per 8mg/mL vial) References
United States $23,000 GoodRx Krystexxa Price
United Kingdom £18,000 NHS Krystexxa Price
Canada $25,000 Canada Drugs Krystexxa Price
Australia $22,000 PBS Krystexxa Price
India ₹1,500,000 1mg Krystexxa Price

Top 5 Global Brands

  • Krystexxa (Horizon Therapeutics): The original brand of pegloticase used for the treatment of chronic gout.
  • Uloric (Takeda Pharmaceuticals): Used for chronic management of hyperuricemia in patients with gout.
  • Zyloprim (GlaxoSmithKline): Another medication used for the long-term management of gout.
  • Probenecid (multiple manufacturers): A medication that increases uric acid excretion in the urine.
  • Zurampic (Ironwood Pharmaceuticals): Used in combination with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with gout.
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