kyprolis (carflizomib) 60mg/vial


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How It Works

Kyprolis (carfilzomib) is a proteasome inhibitor used in the treatment of multiple myeloma. It works by blocking the proteasome, a protein complex responsible for degrading unneeded or damaged proteins within cells. By inhibiting the proteasome, carfilzomib disrupts the degradation of these proteins, leading to an accumulation of proteins in the cancer cells. This accumulation causes stress and ultimately induces apoptosis (cell death) in the malignant cells, thereby reducing the tumor burden.

List of Side Effects

  • Fatigue
  • Nausea
  • Diarrhea
  • Shortness of breath
  • Fever
  • Thrombocytopenia (low platelet count)
  • Anemia (low red blood cell count)
  • Hypertension
  • Peripheral neuropathy
  • Heart failure

List of Indications

  • Treatment of patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy, in combination with other medications (such as lenalidomide and dexamethasone).

List of Contraindications

  • Hypersensitivity to carfilzomib or any of its excipients
  • Severe hepatic impairment
  • Pregnancy
  • Severe cardiac issues including recent myocardial infarction or unstable angina

Price in Different Countries

Country Price (USD) Reference Website
United States $10,000
United Kingdom ?8,500 NHS UK
Canada $13,000 CAD
Australia $14,000 AUD Chemist Warehouse
India ?750,000 INR Medlife
Pakistan ? 2,000,000 PKR

Top 5 Global Brands

  1. Kyprolis (Carfilzomib) – Amgen
  2. Velcade (Bortezomib) – Takeda Oncology
  3. Revlimid (Lenalidomide) – Bristol Myers Squibb
  4. Darzalex (Daratumumab) – Janssen
  5. Pomalyst (Pomalidomide) – Bristol Myers Squibb
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