LANVIS 40 MG 25 TB

Lanvis (generic name: mercaptopurine) is an oral medication used primarily in the treatment of various cancers, including leukemia. It is classified as an antimetabolite, which means it interferes with the normal metabolism of cells, particularly those that are rapidly dividing, such as cancer cells.

How Lanvis Works

Mechanism of Action

1. Antimetabolite Action:
   • Lanvis functions by inhibiting the synthesis of nucleic acids, which are essential for DNA and RNA production. This interference disrupts the normal process of cell replication and division.
2. Purine Analog:
   • It acts as a purine analog, mimicking the natural purine bases involved in DNA and RNA synthesis. By doing so, it inhibits the proliferation of cancer cells by preventing their growth and replication.
3. Inhibition of Enzymes:
   • Lanvis inhibits several key enzymes involved in the purine metabolism, including hypoxanthine-guanine phosphoribosyltransferase (HGPRT). This action reduces the availability of purine nucleotides required for DNA and RNA synthesis.
4. Selective Toxicity:
   • Although Lanvis affects both cancerous and normal rapidly dividing cells, its primary impact is on cancer cells due to their higher rate of division and reliance on purine metabolism.

Side Effects

Common Side Effects

• Nausea and Vomiting:
  • Patients may experience nausea and vomiting, which can usually be managed with antiemetic medications.
• Diarrhea:
  • Diarrhea is a frequent side effect that may require dietary adjustments or medication.
• Loss of Appetite:
  • A decrease in appetite can occur, potentially leading to weight loss.
• Fatigue:
  • General tiredness or fatigue is common among patients taking Lanvis.

Serious Side Effects

• Bone Marrow Suppression:
  • Lanvis can lead to a decrease in blood cell counts, including red blood cells, white blood cells, and platelets, increasing the risk of infections, anemia, and bleeding.
• Liver Toxicity:
  • Liver function abnormalities or liver damage may occur, requiring regular monitoring of liver enzymes.
• Increased Risk of Infections:
  • Due to its impact on white blood cell counts, there is a higher risk of infections.
• Allergic Reactions:
  • Severe allergic reactions, including rash, itching, swelling, and difficulty breathing, may occur.

Indications

Lanvis is indicated for:

• Acute Lymphoblastic Leukemia (ALL):
  • Treatment of acute lymphoblastic leukemia, often in combination with other chemotherapy agents.
• Acute Myeloid Leukemia (AML):
  • Used in the treatment of acute myeloid leukemia.
• Chronic Myeloid Leukemia (CML):
  • Can be used as part of the treatment regimen for chronic myeloid leukemia.
• Other Hematologic Malignancies:
  • Lanvis may also be utilized in the treatment of other hematologic cancers as determined by the healthcare provider.

Contraindications

Lanvis is contraindicated in:

• Hypersensitivity:
  • Known hypersensitivity to mercaptopurine or any of its components.
• Pregnancy:
  • Lanvis should not be used during pregnancy due to the risk of harm to the developing fetus.
• Severe Liver Disease:
  • Patients with severe liver impairment should not use Lanvis due to the risk of exacerbating liver issues.
• Active Infection:
  • Use of Lanvis in patients with active infections should be avoided due to the increased risk of severe infections.

Price in Different Countries

The price of Lanvis 40 mg varies by country and healthcare system. Below is a table with approximate price ranges and references.

Country	Price (Per 25 Tablets)	Reference
United States	$150 – $200	GoodRx
United Kingdom	£100 – £120	NHS UK
Canada	CAD $160 – $180	Health Canada
Australia	AUD $180 – $200	PBS Australia
India	₹10,000 – ₹12,000	Medlife

Top 5 Global Brands

1. Lanvis – GlaxoSmithKline:
   • The original manufacturer of mercaptopurine, known for its established efficacy and reliability.
2. Lanvis – Teva Pharmaceuticals:
   • Offers a generic version of Lanvis, providing a cost-effective alternative.
3. Lanvis – Mylan:
   • Produces a generic form of mercaptopurine, ensuring broad availability.
4. Lanvis – Sandoz:
   • Known for its quality generic version of Lanvis, meeting high standards.
5. Lanvis – Dr. Reddy’s Laboratories:
   • Provides a generic option of Lanvis, adhering to rigorous quality controls.