Lenalid 25mg (Lenalidomide) Cap 10S

How It Works

Lenalidomide is an immunomodulatory agent primarily used in the treatment of multiple myeloma and myelodysplastic syndromes. It works by altering the immune system and targeting cancer cells directly. Lenalidomide modulates the activity of the immune system by inhibiting pro-inflammatory cytokines, stimulating T-cells, and enhancing natural killer (NK) cell function. It also inhibits angiogenesis (the growth of new blood vessels in tumors) and induces apoptosis (programmed cell death) in cancer cells. Mechanisms:

• Immunomodulation: Enhances the body’s immune response against cancer cells.
• Anti-angiogenesis: Restricts blood supply to the tumor, inhibiting its growth.
• Direct tumor cell inhibition: Promotes cell death and limits cell proliferation.

Side Effects

• Fatigue
• Diarrhea
• Nausea
• Rash
• Low blood counts (anemia, neutropenia, thrombocytopenia)
• Constipation
• Peripheral neuropathy (numbness or tingling in extremities)
• Fever
• Infections
• Dizziness
• Deep vein thrombosis (blood clots)

Indications

Lenalid 10mg (Lenalidomide) is used for:

• Multiple Myeloma: In combination with other medications for newly diagnosed or previously treated multiple myeloma.
• Myelodysplastic Syndromes (MDS): Specifically for patients with a deletion 5q cytogenetic abnormality.
• Mantle Cell Lymphoma (MCL): In patients whose disease has relapsed or progressed after two prior therapies.
• Follicular and marginal zone lymphoma: For relapsed or refractory disease.

Contraindications

• Pregnancy: Lenalidomide can cause severe birth defects or fetal death. It is contraindicated in pregnant women or those planning to become pregnant.
• Breastfeeding: The safety of Lenalidomide during breastfeeding has not been established.
• Severe liver or kidney impairment: Caution is advised in patients with severe hepatic or renal issues.
• Hypersensitivity: Contraindicated in individuals with known hypersensitivity to Lenalidomide or any of its components.
• Blood clotting disorders: In patients at risk for thrombosis, Lenalidomide should be used cautiously.

Price Table in Different Countries

Country	Price (10 capsules)	Reference
United States	$580	GoodRx
United Kingdom	£450	NHS
India	₹7,500	1mg
Canada	CAD 750	PharmacyChecker
Australia	AUD 900	PBS

Top 5 Global Brands

1. Revlimid (Celgene/Bristol-Myers Squibb)
2. Lenalid (Natco Pharma)
3. Lenangio (Cipla)
4. Lenome (Sun Pharma)
5. Myeloid (Dr. Reddy’s Laboratories)