LUCRIN D. 11.25 MG 3AY PRE INJ

Lucrin D. 11.25 mg 3AY Pre Inj is a medication used primarily in the treatment of hormone-sensitive conditions. It is a formulation of leuprolide acetate, a type of luteinizing hormone-releasing hormone (LHRH) agonist. Lucrin is commonly utilized in managing conditions such as prostate cancer, endometriosis, and precocious puberty. This specific formulation is designed to provide a prolonged release of the drug over three months.

How It Works

Mechanism of Action

Lucrin D. 11.25 mg functions by altering the levels of certain hormones in the body. Here’s how it works:

1. Suppression of Gonadotropins:
   • Lucrin acts on the pituitary gland to suppress the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This suppression leads to a decrease in the production of sex hormones such as testosterone in men and estrogen in women.
2. Reduction of Hormone Levels:
   • By lowering the levels of these hormones, Lucrin effectively reduces the stimulation of hormone-dependent tissues and tumors, such as those in prostate cancer and endometriosis.
3. Reversible Effect:
   • Although Lucrin initially stimulates hormone release due to its agonistic effect, it eventually leads to downregulation of hormone production, resulting in a reduced level of hormones over time.

Side Effects

Common Side Effects

• Hot Flashes:
  • Patients may experience episodes of intense heat and sweating.
• Headache:
  • Headaches are a frequent side effect.
• Injection Site Reactions:
  • Redness, pain, or swelling at the injection site can occur.
• Nausea:
  • Some individuals may feel nauseous.

Serious Side Effects

• Mood Changes:
  • Severe mood swings, including depression or anxiety, may be observed.
• Bone Density Loss:
  • Long-term use can lead to decreased bone density, increasing the risk of fractures.
• Cardiovascular Issues:
  • Rarely, patients may experience cardiovascular problems such as hypertension.
• Sexual Dysfunction:
  • Sexual side effects, including reduced libido or erectile dysfunction, can occur.
• Allergic Reactions:
  • Severe allergic reactions, such as rash, itching, or swelling, though rare, require immediate medical attention.

Indications

Lucrin D. 11.25 mg is indicated for:

• Prostate Cancer:
  • Used in the treatment of advanced prostate cancer to reduce testosterone levels and slow tumor growth.
• Endometriosis:
  • Helps in managing endometriosis by lowering estrogen levels, thus reducing the growth of endometrial tissue.
• Precocious Puberty:
  • Treats children with early onset puberty by delaying the progression of sexual development.
• Uterine Fibroids:
  • Used to shrink uterine fibroids by reducing estrogen levels.

Contraindications

Lucrin D. 11.25 mg is contraindicated in:

• Hypersensitivity:
  • Known hypersensitivity to leuprolide acetate or any component of the formulation.
• Pregnancy:
  • Should not be used during pregnancy as it may harm the fetus. Effective contraception is required during treatment.
• Breastfeeding:
  • It is not recommended for breastfeeding women due to potential effects on milk production and infant health.
• Severe Osteoporosis:
  • Caution is advised in patients with severe osteoporosis, as long-term use can exacerbate bone density loss.
• Pre-existing Cardiovascular Conditions:
  • Should be used with caution in patients with severe cardiovascular conditions due to the risk of exacerbating these issues.

Price in Different Countries

The price of Lucrin D. 11.25 mg varies by country. Here is a table with approximate prices and references.

Country	Price (Per Injection)	Reference
United States	$1,500 – $1,800	GoodRx
United Kingdom	£1,200 – £1,500	NHS UK
Canada	CAD $1,600 – $1,900	Health Canada
Australia	AUD $1,700 – $2,000	PBS Australia
India	₹45,000 – ₹55,000	Medlife

Top 5 Global Brands

1. Lucrin – AbbVie:
   • The original brand of leuprolide acetate, known for its efficacy in treating hormone-sensitive conditions.
2. Eligard – Sanofi:
   • A brand of leuprolide acetate that offers similar therapeutic effects.
3. Viadur – Eli Lilly:
   • Another formulation of leuprolide acetate, providing long-term hormone suppression.
4. Leuprorelin – Various Generics:
   • Multiple generic versions of leuprolide acetate available in different markets.
5. Prostap – Ferring Pharmaceuticals:
   • A competitor brand that also utilizes leuprolide acetate for treating hormone-dependent conditions.