Mavyret (Glecaprevir 100 mg & Pibrentasvir 40mg) 21 Tablets

How It Works

Mavyret contains two direct-acting antivirals: glecaprevir and pibrentasvir. Glecaprevir is a protease inhibitor that blocks the NS3/4A protease enzyme, which is essential for the viral replication of HCV. Pibrentasvir is an NS5A inhibitor that interferes with the NS5A protein, which is also necessary for viral replication. By inhibiting these enzymes, Mavyret prevents the virus from multiplying and helps the body eliminate the infection.

Side Effects

• Headache
• Fatigue
• Nausea
• Diarrhea
• Elevated liver enzymes

Indications

• Chronic hepatitis C virus (HCV) infection in adults and children aged 12 years and older, across all six genotypes (1-6)

Contraindications

• Severe hepatic impairment (Child-Pugh C)
• Co-administration with atazanavir or rifampin
• Hypersensitivity to any of the components of Mavyret

Price Comparison in Different Countries

Country	Price (per box of 21 tablets)	Reference
Pakistan	Approximately PKR 210,000	Dawaai Pakistan
United States	USD 13,200	GoodRx
United Kingdom	GBP 10,000	NHS UK
Canada	CAD 16,000	Health Canada
Australia	AUD 17,000	PBS Australia

Top 5 Global Brands

1. Gilead Sciences
2. AbbVie
3. Roche
4. Merck & Co.
5. Bristol-Myers Squibb

Conclusion

Mavyret (Glecaprevir 100 mg & Pibrentasvir 40 mg) is a potent combination therapy for treating chronic hepatitis C virus (HCV) infection across all six genotypes. By targeting and inhibiting essential enzymes for viral replication, Mavyret helps in effectively reducing the viral load and ultimately clearing the infection from the body. The medication, however, comes with some side effects and contraindications that need to be carefully considered and managed by healthcare providers. The price of Mavyret varies significantly across different countries, reflecting global disparities in healthcare access. Patients should consult with their healthcare providers to determine if Mavyret is the right treatment option for their condition and explore possible financial assistance options if needed.