MOZOBIL 20 MG /ML FLC

Mozobil (generic name: Plerixafor) is a medication used to enhance the mobilization of hematopoietic stem cells into the peripheral blood for collection and subsequent transplantation. It is commonly administered in patients with certain types of cancer, including lymphoma and multiple myeloma, who are preparing for stem cell transplantation. Mozobil is used in conjunction with other medications such as G-CSF (granulocyte-colony stimulating factor) to facilitate the harvesting of stem cells, which are then used in transplant procedures to restore healthy blood cells.

How Mozobil Works

Mechanism of Action

1. CXCR4 Antagonism:
   • Mozobil is a specific antagonist of the CXCR4 (C-X-C chemokine receptor type 4). By blocking CXCR4, Mozobil disrupts the interaction between CXCR4 and its ligand, CXCL12 (also known as SDF-1), which normally retains stem cells in the bone marrow.
2. Stem Cell Mobilization:
   • By inhibiting the CXCR4-CXCL12 interaction, Mozobil facilitates the release of hematopoietic stem cells from the bone marrow into the bloodstream. This mobilization is crucial for the collection of these cells for transplantation.
3. Increased Stem Cell Yield:
   • The enhanced mobilization of stem cells into the peripheral blood allows for a more efficient collection process. This increases the likelihood of obtaining an adequate number of stem cells for successful transplantation.
4. Use in Conjunction with G-CSF:
   • Mozobil is typically used in combination with G-CSF, which stimulates the production of white blood cells. Together, they improve the overall yield of stem cells and enhance the success of the transplantation procedure.

Side Effects

Common Side Effects

• Nausea:
  • Mild to moderate nausea may occur as a common reaction to the medication.
• Diarrhea:
  • Gastrointestinal upset, including diarrhea, is frequently reported.
• Fatigue:
  • General tiredness or fatigue is common among patients receiving Mozobil.
• Headache:
  • Patients may experience headaches during treatment.
• Injection Site Reactions:
  • Pain, redness, or swelling at the site of injection can occur.

Serious Side Effects

• Infection Risk:
  • Due to the mobilization of stem cells, there may be an increased risk of infections, especially when used with other immunosuppressive treatments.
• Gastrointestinal Issues:
  • Severe gastrointestinal problems such as persistent vomiting or dehydration may occur.
• Allergic Reactions:
  • Rare but serious allergic reactions, including rash, itching, or difficulty breathing, may occur.
• Severe Headache:
  • In rare cases, patients may experience severe headaches that require medical attention.
• Thrombocytopenia:
  • A reduction in platelet count, which can increase the risk of bleeding and bruising.

Indications

Mozobil is indicated for:

• Hematopoietic Stem Cell Mobilization:
  • Used to mobilize hematopoietic stem cells in patients with non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM) who are undergoing stem cell transplantation.
• Pre-Transplantation Preparation:
  • To prepare patients for autologous stem cell transplantation by enhancing the yield of stem cells collected from the peripheral blood.

Contraindications

Mozobil should not be used in the following conditions:

• Hypersensitivity:
  • Known hypersensitivity or allergic reactions to Mozobil or any of its components.
• Severe Kidney Impairment:
  • Use is contraindicated in patients with severe renal impairment, as the drug is primarily eliminated through the kidneys.
• Pregnancy:
  • Not recommended during pregnancy due to potential harm to the fetus. Effective contraception should be used during treatment.
• Breastfeeding:
  • Use is contraindicated in breastfeeding mothers due to the potential for adverse effects on the infant.
• Active Infections:
  • Patients with active infections should not use Mozobil due to the risk of exacerbating these conditions.

Price in Different Countries

The price of Mozobil 20 mg/ml can vary based on geographic location, healthcare systems, and pricing agreements. Below is a table showing the approximate price range in various countries.

Country	Price (Per 20 mg/ML Vial)	Reference
United States	$6,000 – $8,000	GoodRx
United Kingdom	£4,500 – £6,000	NHS UK
Canada	CAD $7,000 – $9,000	Canada Drugs
Australia	AUD $8,500 – $10,000	PBS Australia
India	₹350,000 – ₹450,000	1mg

Top 5 Global Brands

1. Mozobil – Genzyme (Sanofi):
   • The original and leading brand of Plerixafor, widely used and recognized globally for its efficacy in stem cell mobilization.
2. Plerixafor Injection – Cipla:
   • A generic version produced by Cipla, available in various markets, including India.
3. Plerixafor – Dr. Reddy’s Laboratories:
   • Another major manufacturer of Plerixafor, providing affordable alternatives in different regions.
4. Mozobil – Mylan:
   • Available in certain countries under the Mylan brand, providing similar efficacy to the original formulation.
5. Plerixafor – Teva Pharmaceuticals:
   • A prominent generic brand that is widely used in the treatment of cancers requiring stem cell mobilization.