• 0 items in quote

    No products in the Quote Basket.

  • NAVELBINE 10 MG 1 FLC

    Quantity

    Get Price

    Get it to Germany within 10 working days with standard delivery.

    Fast delivery to Germany

    Easy Returns & Exchanges

    Ask About This Product

    Condition : New

    0

    From UAE

    To Germany

    in 5-10 days

    Description

    Navelbine (generic name: Vinorelbine) is a chemotherapy medication used in the treatment of various types of cancer, including non-small cell lung cancer (NSCLC) and breast cancer. It is classified as a vinca alkaloid, a class of drugs derived from the periwinkle plant. Navelbine works by interfering with the ability of cancer cells to divide and proliferate.

    How Navelbine Works

    Mechanism of Action

    1. Inhibition of Microtubule Formation:
      • Navelbine acts by binding to tubulin, a protein that is crucial for the formation of microtubules. Microtubules are essential components of the cell’s cytoskeleton and play a key role in cell division.
    2. Disruption of Mitotic Spindle:
      • By binding to tubulin, Navelbine prevents the proper formation of the mitotic spindle, which is necessary for chromosomes to be accurately divided between the two daughter cells during mitosis. This disruption leads to the arrest of cell division.
    3. Induction of Apoptosis:
      • The interference with cell division ultimately triggers apoptosis, or programmed cell death, in cancer cells. This helps reduce the number of cancerous cells in the body.
    4. Selective Toxicity:
      • Navelbine primarily targets rapidly dividing cells, which include cancer cells. However, it can also affect normal cells that divide quickly, leading to side effects.

    Side Effects

    Common Side Effects

    • Nausea and Vomiting:
      • Nausea and vomiting are frequent side effects, though they can usually be managed with anti-emetic medications.
    • Hair Loss:
      • Temporary hair loss or thinning may occur during treatment.
    • Constipation:
      • Patients may experience constipation, which can be managed with dietary adjustments and medications.
    • Fatigue:
      • General fatigue and weakness are common during treatment.

    Serious Side Effects

    • Bone Marrow Suppression:
      • Navelbine can cause significant suppression of bone marrow function, leading to decreased production of blood cells. This may result in anemia, increased risk of infections, and bleeding problems.
    • Peripheral Neuropathy:
      • Nerve damage can occur, leading to symptoms such as numbness, tingling, or pain in the hands and feet.
    • Pulmonary Toxicity:
      • There is a risk of lung damage, including interstitial lung disease or pneumonitis.
    • Infection Risk:
      • Due to bone marrow suppression, there is an increased risk of infections that may require medical intervention.
    • Severe Allergic Reactions:
      • Rare but severe allergic reactions can occur, including anaphylaxis.

    Indications

    Navelbine is indicated for:
    • Non-Small Cell Lung Cancer (NSCLC):
      • Used in the treatment of NSCLC, either as a first-line therapy or in combination with other drugs.
    • Breast Cancer:
      • Employed in the treatment of metastatic breast cancer, particularly after other treatments have failed.
    • Other Cancers:
      • May be used off-label for other malignancies as determined by a healthcare provider.

    Contraindications

    Navelbine should not be used in the following conditions:
    • Hypersensitivity:
      • Known hypersensitivity to vinorelbine or any of its components.
    • Severe Bone Marrow Depression:
      • Contraindicated in patients with severe bone marrow suppression or aplastic anemia.
    • Severe Liver Dysfunction:
      • Should be avoided in patients with severe liver impairment.
    • Pregnancy:
      • Not recommended during pregnancy due to potential harm to the fetus. Effective contraception is required for women of childbearing potential.
    • Breastfeeding:
      • Not advised for use in breastfeeding women, as it may affect the infant.

    Price in Different Countries

    The price of Navelbine 10 mg varies by country and specific healthcare system. Below is a table showing the approximate price range in various countries.
    Country Price (Per 10 mg Vial) Reference
    United States $150 – $200 GoodRx
    United Kingdom £120 – £180 NHS UK
    Canada CAD $180 – $250 Canada Drugs
    Australia AUD $200 – $280 PBS Australia
    India ₹10,000 – ₹15,000 1mg

    Top 5 Global Brands

    1. Navelbine – Pierre Fabre:
      • The original brand of vinorelbine, widely used and recognized for its effectiveness in treating lung and breast cancers.
    2. Vemurafenib – Genentech:
      • A well-known alternative for various types of cancer, offering competitive options in the market.
    3. Oncovin – Bristol-Myers Squibb:
      • Another major brand offering vincristine, a related vinca alkaloid with similar applications.
    4. Vincasar PFS – Pfizer:
      • Provides an alternative vinca alkaloid treatment, often used in combination with other drugs.
    5. Vincristine – Teva Pharmaceuticals:
      • A generic option for vincristine, ensuring broader accessibility and affordability.
    Shopping Cart
    NAVELBINE 10 MG 1 FLC
    Get Price