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  • NOLVADEX-D 20 MG 30 TB

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    Description

    Nolvadex (generic name: Tamoxifen Citrate) is a medication used primarily in the treatment of breast cancer. It is classified as a selective estrogen receptor modulator (SERM) and works by interfering with the effects of estrogen in the breast tissue. Nolvadex is utilized for both treatment and prevention of breast cancer, particularly in hormone receptor-positive cases.

    How Nolvadex Works

    Mechanism of Action

    1. Estrogen Receptor Antagonism:
      • Nolvadex acts as an antagonist at estrogen receptors in breast tissue. By binding to these receptors, it blocks estrogen from attaching to them. Since many breast cancers grow in response to estrogen, Nolvadex helps to slow or stop the growth of estrogen-dependent tumors.
    2. Partial Agonism in Other Tissues:
      • While Nolvadex blocks estrogen in breast tissue, it can act as a partial agonist in other tissues like the uterus and bone. This partial agonistic activity can help prevent bone loss and maintain bone density.
    3. Cell Growth Inhibition:
      • By preventing estrogen from binding to its receptors, Nolvadex inhibits the proliferation of breast cancer cells, leading to a reduction in tumor size and spread.
    4. Prevention of Recurrence:
      • In addition to treating existing breast cancer, Nolvadex is used to reduce the risk of cancer recurrence in patients who have already undergone treatment.

    Side Effects

    Common Side Effects

    • Hot Flashes:
      • Many patients experience hot flashes, which can be managed with lifestyle adjustments and medication.
    • Nausea and Vomiting:
      • These symptoms are common but can often be controlled with anti-emetic drugs.
    • Fatigue:
      • General tiredness or fatigue may occur and can be managed with rest and proper nutrition.
    • Vaginal Discharge:
      • Some women may experience a vaginal discharge, which is generally not serious but should be monitored.

    Serious Side Effects

    • Increased Risk of Endometrial Cancer:
      • Nolvadex can increase the risk of endometrial cancer, so regular gynecological check-ups are recommended.
    • Blood Clots:
      • There is an elevated risk of deep vein thrombosis (DVT) and pulmonary embolism (PE), which requires prompt medical attention if symptoms occur.
    • Stroke:
      • Increased risk of stroke, particularly in older patients, may occur.
    • Liver Toxicity:
      • Potential liver issues, such as hepatitis or liver enzyme abnormalities, may require monitoring.
    • Ocular Toxicity:
      • Rarely, vision changes or eye problems can occur and should be evaluated by an ophthalmologist.

    Indications

    Nolvadex is indicated for:
    • Breast Cancer Treatment:
      • Used for the treatment of estrogen receptor-positive breast cancer in both premenopausal and postmenopausal women.
    • Breast Cancer Prevention:
      • Prescribed for women at high risk of breast cancer to reduce the likelihood of developing the disease.
    • Breast Cancer Recurrence Prevention:
      • Employed in patients who have been treated for breast cancer to prevent recurrence.
    • McCune-Albright Syndrome:
      • Sometimes used in the management of McCune-Albright syndrome to help with hormone-related issues.

    Contraindications

    Nolvadex should not be used in the following conditions:
    • Hypersensitivity:
      • Known hypersensitivity to tamoxifen or any of the excipients in the formulation.
    • Pregnancy:
      • Not recommended during pregnancy due to potential harm to the fetus. Effective contraception should be used during treatment.
    • Active or History of Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE):
      • Patients with a history or active symptoms of blood clots should avoid using Nolvadex due to an increased risk of clotting complications.
    • Severe Liver Dysfunction:
      • Contraindicated in patients with severe liver impairment due to the risk of exacerbating liver issues.
    • Endometrial Disorders:
      • Patients with a history of endometrial cancer or severe endometrial hyperplasia should avoid Nolvadex.

    Price in Different Countries

    The price of Nolvadex 10 mg varies by country and specific healthcare system. Below is a table showing the approximate price range in various countries.  
    Country Price (Per 10 mg Tablet) Reference
    United States $100 – $150 GoodRx
    United Kingdom £80 – £120 NHS UK
    Canada CAD $110 – $160 Canada Drugs
    Australia AUD $130 – $180 PBS Australia
    India ₹4,000 – ₹6,000 1mg

    Top 5 Global Brands

    1. Nolvadex – AstraZeneca:
      • The original brand of tamoxifen, known for its established efficacy and quality.
    2. Tamoxifen – Mylan:
      • A widely recognized generic version of Nolvadex, offering cost-effective treatment options.
    3. Tamoxifen – Teva:
      • Another reputable generic version, providing affordable alternatives to the brand name.
    4. Tamoxifen – Sandoz:
      • Offers a generic version with competitive pricing and availability.
    5. Tamoxifen – Apotex:
      • Provides a widely available generic option for tamoxifen therapy.
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