Nucala 100 mg powder for solution for injection


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Nucala (mepolizumab) is a prescription medication used to treat severe eosinophilic asthma and other eosinophilic conditions. Each vial contains 100 mg of mepolizumab as a powder that must be reconstituted and administered as an injection by a healthcare professional.

How It Works

Mepolizumab is a monoclonal antibody that targets and inhibits interleukin-5 (IL-5), a cytokine that plays a key role in the growth, activation, and survival of eosinophils. By blocking IL-5, mepolizumab reduces the number of eosinophils in the blood, which helps control inflammation and symptoms in patients with eosinophilic conditions.

Side Effects

  • Headache
  • Injection site reactions (pain, redness, swelling)
  • Back pain
  • Fatigue
  • Upper respiratory tract infections
  • Nausea
  • Hypersensitivity reactions (rash, itching, swelling)


  • Severe eosinophilic asthma in adults and adolescents aged 12 years and older
  • Eosinophilic granulomatosis with polyangiitis (EGPA)
  • Hypereosinophilic syndrome (HES)


  • Known hypersensitivity to mepolizumab or any of its components
  • Acute bronchospasm or status asthmaticus

Price in Different Countries

Country Price (USD) Reference
United States $3,200 GoodRx
Canada $2,800 Canada Pharmacy
United Kingdom ?2,500 UK Meds
Australia AUD 4,000 Australia Pharmacy
India ?300,000 India Meds

Top 5 Global Brands

  • GlaxoSmithKline (GSK) – Manufacturer of Nucala
  • Novartis
  • Roche
  • Sanofi
  • Pfizer
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