Orencia Abatacept 125mg Injection

How it Works

Orencia (abatacept) is a biologic medication used to treat autoimmune conditions such as rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis. It works by modulating the immune system. Abatacept is a fusion protein composed of the extracellular domain of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) linked to a modified Fc portion of human immunoglobulin G1 (IgG1). By binding to CD80 and CD86 on antigen-presenting cells, abatacept inhibits the co-stimulation of T cells. This action prevents the activation of T cells, which play a critical role in the inflammatory process of autoimmune diseases, thereby reducing inflammation and tissue damage.

Side Effects

• Headache
• Nausea
• Upper respiratory tract infections
• Nasopharyngitis (common cold)
• Fatigue
• Urinary tract infections
• Cough
• Back pain
• Hypertension (high blood pressure)
• Rash
• Infusion-related reactions
• Dizziness

Indications

• Moderate to severe rheumatoid arthritis in adults, as a monotherapy or in combination with other disease-modifying antirheumatic drugs (DMARDs)
• Moderate to severe juvenile idiopathic arthritis in patients 2 years of age and older
• Active psoriatic arthritis in adults

Contraindications

• Hypersensitivity to abatacept or any of its excipients
• Severe infections, such as sepsis or opportunistic infections
• Concurrent use with TNF antagonists (due to increased risk of infections)
• Immunocompromised patients

Price Comparison in Different Countries

Country	Price (USD)	Website
United States	$4,000 per dose	GoodRx
Canada	$3,500 per dose	PharmacyChecker
United Kingdom	?3,000 per dose	NHS
Australia	AUD 5,200 per dose	PBS
India	?280,000 per dose	Medindia

Top 5 Global Brands

1. Orencia (Bristol-Myers Squibb)
2. Humira (AbbVie)
3. Enbrel (Amgen)
4. Remicade (Janssen Biotech, Inc.)
5. Simponi (Janssen Biotech, Inc.)