Orencia Abatacept 125mg Injection


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How it Works

Orencia (abatacept) is a biologic medication used to treat autoimmune conditions such as rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis. It works by modulating the immune system. Abatacept is a fusion protein composed of the extracellular domain of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) linked to a modified Fc portion of human immunoglobulin G1 (IgG1). By binding to CD80 and CD86 on antigen-presenting cells, abatacept inhibits the co-stimulation of T cells. This action prevents the activation of T cells, which play a critical role in the inflammatory process of autoimmune diseases, thereby reducing inflammation and tissue damage.

Side Effects

  • Headache
  • Nausea
  • Upper respiratory tract infections
  • Nasopharyngitis (common cold)
  • Fatigue
  • Urinary tract infections
  • Cough
  • Back pain
  • Hypertension (high blood pressure)
  • Rash
  • Infusion-related reactions
  • Dizziness


  • Moderate to severe rheumatoid arthritis in adults, as a monotherapy or in combination with other disease-modifying antirheumatic drugs (DMARDs)
  • Moderate to severe juvenile idiopathic arthritis in patients 2 years of age and older
  • Active psoriatic arthritis in adults


  • Hypersensitivity to abatacept or any of its excipients
  • Severe infections, such as sepsis or opportunistic infections
  • Concurrent use with TNF antagonists (due to increased risk of infections)
  • Immunocompromised patients

Price Comparison in Different Countries

Country Price (USD) Website
United States $4,000 per dose GoodRx
Canada $3,500 per dose PharmacyChecker
United Kingdom ?3,000 per dose NHS
Australia AUD 5,200 per dose PBS
India ?280,000 per dose Medindia

Top 5 Global Brands

  1. Orencia (Bristol-Myers Squibb)
  2. Humira (AbbVie)
  3. Enbrel (Amgen)
  4. Remicade (Janssen Biotech, Inc.)
  5. Simponi (Janssen Biotech, Inc.)
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