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  • Orencia Abatacept 125mg Injection

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    Description

    How it Works

    Orencia (abatacept) is a biologic medication used to treat autoimmune conditions such as rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis. It works by modulating the immune system. Abatacept is a fusion protein composed of the extracellular domain of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) linked to a modified Fc portion of human immunoglobulin G1 (IgG1). By binding to CD80 and CD86 on antigen-presenting cells, abatacept inhibits the co-stimulation of T cells. This action prevents the activation of T cells, which play a critical role in the inflammatory process of autoimmune diseases, thereby reducing inflammation and tissue damage.

    Side Effects

    • Headache
    • Nausea
    • Upper respiratory tract infections
    • Nasopharyngitis (common cold)
    • Fatigue
    • Urinary tract infections
    • Cough
    • Back pain
    • Hypertension (high blood pressure)
    • Rash
    • Infusion-related reactions
    • Dizziness

    Indications

    • Moderate to severe rheumatoid arthritis in adults, as a monotherapy or in combination with other disease-modifying antirheumatic drugs (DMARDs)
    • Moderate to severe juvenile idiopathic arthritis in patients 2 years of age and older
    • Active psoriatic arthritis in adults

    Contraindications

    • Hypersensitivity to abatacept or any of its excipients
    • Severe infections, such as sepsis or opportunistic infections
    • Concurrent use with TNF antagonists (due to increased risk of infections)
    • Immunocompromised patients

    Price Comparison in Different Countries

    Country Price (USD) Website
    United States $4,000 per dose GoodRx
    Canada $3,500 per dose PharmacyChecker
    United Kingdom ?3,000 per dose NHS
    Australia AUD 5,200 per dose PBS
    India ?280,000 per dose Medindia

    Top 5 Global Brands

    1. Orencia (Bristol-Myers Squibb)
    2. Humira (AbbVie)
    3. Enbrel (Amgen)
    4. Remicade (Janssen Biotech, Inc.)
    5. Simponi (Janssen Biotech, Inc.)
     
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    Orencia Abatacept 125mg Injection
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