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  • Orenitram (treprostinil) 1mg

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    Description

    Orenitram is a brand name for treprostinil, a medication used for the treatment of pulmonary arterial hypertension (PAH). It is part of a class of drugs known as prostacyclin analogs and is specifically designed to help improve exercise capacity in patients with PAH. Orenitram is available in oral tablet form, making it a convenient option for patients requiring continuous treatment. This medication represents an important advancement in the management of PAH, offering a prostacyclin pathway therapy that can be taken orally.

    How It Works

    Treprostinil, the active ingredient in Orenitram, works by mimicking the effects of prostacyclin, a naturally occurring substance in the body that dilates blood vessels and inhibits platelet aggregation. Here’s a detailed explanation of how it works: 1. **Vasodilation**: Treprostinil acts as a potent vasodilator, relaxing the smooth muscles in the walls of blood vessels, particularly in the pulmonary and systemic circulation. This leads to a reduction in pulmonary vascular resistance, decreasing the workload on the right side of the heart. 2. **Inhibition of Platelet Aggregation**: By inhibiting the aggregation of platelets, treprostinil reduces the risk of blood clots forming in the pulmonary arteries, which can worsen PAH. 3. **Improvement of Blood Flow**: Treprostinil improves overall blood flow through the lungs and to the rest of the body, enhancing oxygen delivery and improving exercise capacity in patients with PAH. 4. **Anti-inflammatory Effects**: Treprostinil has anti-inflammatory properties that may contribute to its therapeutic effects by reducing inflammation in the pulmonary vasculature.

    Indications

    Orenitram is indicated for the treatment of:
    • Pulmonary Arterial Hypertension (PAH): It is used to improve exercise capacity in adult patients with WHO Group 1 PAH.
    **Note:** Orenitram’s effectiveness may vary based on the underlying cause of PAH, and it is typically used as part of a combination therapy in patients with advanced disease.

    Side Effects

    Common side effects of Orenitram may include:
    • Headache
    • Nausea
    • Diarrhea
    • Flushing
    • Jaw pain
    • Abdominal pain
    • Vomiting
    • Edema (swelling of the legs or ankles)
    • Dizziness
    • Cough
    Serious side effects that require immediate medical attention include:
    • **Hypotension**: Severe drops in blood pressure can occur, leading to dizziness or fainting.
    • **Bleeding**: Due to its anti-platelet effects, treprostinil may increase the risk of bleeding, especially in patients on anticoagulants.
    • **Liver Dysfunction**: Elevated liver enzymes may indicate liver injury and require monitoring.
    • **Pulmonary Edema**: Patients with certain types of pulmonary venous hypertension may experience worsening symptoms.

    Contraindications

    Orenitram is contraindicated in the following situations:
    • Severe Hepatic Impairment: Treprostinil is contraindicated in patients with severe liver dysfunction (Child-Pugh Class C).
    • Known Hypersensitivity: Patients with known hypersensitivity to treprostinil or any of its components should not use Orenitram.
    • Acute Pulmonary Edema: Patients with decompensated heart failure due to severe left-sided heart disease should not be treated with Orenitram.
    • Concomitant Use with CYP2C8 Inhibitors: Strong inhibitors like gemfibrozil can increase treprostinil exposure, necessitating careful consideration or dosage adjustment.

    Pricing Information

    Here is a table detailing the price of Orenitram in various countries:
    Country Price (per 1mg tablet) Reference
    United States $70 – $80 GoodRx
    Canada CAD $90 – $100 DrugBank
    United Kingdom £65 – £75 NHS
    Australia AUD $110 – $120 PBS
    Germany €85 – €95 Apotheken Umschau

    Top 5 Global Brands

    In addition to Orenitram, several pharmaceutical companies manufacture medications for the treatment of pulmonary arterial hypertension. Here are some of the top global brands:
    • Remodulin (treprostinil) – United Therapeutics
    • Tyvaso (treprostinil inhalation) – United Therapeutics
    • Uptravi (selexipag) – Actelion Pharmaceuticals
    • Adempas (riociguat) – Bayer
    • Tracleer (bosentan) – Actelion Pharmaceuticals
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    Orenitram (treprostinil) 1mg
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