Otezla (apremilast) 60 Tablets 30mg


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How It Works

Otezla (generic name apremilast) is a phosphodiesterase 4 (PDE4) inhibitor. It works by inhibiting the activity of PDE4, an enzyme that plays a role in the inflammatory process. By inhibiting PDE4, Otezla helps to reduce the production of inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-23 (IL-23), which are involved in the pathogenesis of certain autoimmune diseases.

Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Upper respiratory tract infection
  • Back pain


  • Otezla is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy.
  • It is also indicated for the treatment of active psoriatic arthritis in adults.


  • Hypersensitivity to apremilast or any component of the formulation
  • Severe renal impairment (creatinine clearance < 30 mL/min)
  • Pregnancy (Otezla may cause fetal harm)

Price Comparison in Different Countries

Country Price (per unit) References
United States $3,000 GoodRx
United Kingdom ?2,500 NHS
Australia AUD 4,000 PBS Australia
Canada CAD 3,500 CADTH
Germany ?2,500 Apotheken Umschau

Top 5 Global Brands

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