Palynziq Prefilled syringe (pegvaliase-pqpz) 20mgPalynziq Prefilled syringe (pegvaliase-pqpz) 20mg
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Description
Palynziq (pegvaliase-pqpz) is a prefilled syringe containing 20 mg of pegvaliase, an enzyme substitution therapy used to treat adults with phenylketonuria (PKU) who have uncontrolled blood phenylalanine (Phe) levels. Palynziq is a PEGylated recombinant phenylalanine ammonia lyase (rAvPAL-PEG) enzyme that helps reduce blood Phe levels by breaking down phenylalanine into harmless components.
How It Works
Palynziq works by providing an alternative metabolic pathway to break down phenylalanine, an amino acid that individuals with PKU cannot properly metabolize. Pegvaliase is an enzyme that converts phenylalanine into ammonia and trans-cinnamic acid, which are then further metabolized and excreted from the body. By reducing the levels of phenylalanine in the blood, Palynziq helps prevent the toxic effects of high phenylalanine levels, which can include neurological and cognitive impairments.Side Effects
- Injection site reactions (redness, swelling, itching)
- Hypersensitivity reactions (rash, fever, itching)
- Arthralgia (joint pain)
- Headache
- Abdominal pain
- Fatigue
- Palpitations
- Nausea
- Vomiting
- Dizziness
Indications
- Long-term treatment of adult patients with phenylketonuria (PKU) who have uncontrolled blood phenylalanine levels.
Contraindications
- Known hypersensitivity to pegvaliase or any of its components.
- Severe allergic reactions to any other enzyme replacement therapies.
- Patients with severe hepatic impairment.
- Patients with a history of anaphylaxis or severe systemic allergic reactions to Pegvaliase.
Price in Different Countries
| Country | Price (per 20 mg prefilled syringe) | References |
|---|---|---|
| United States | $26,000 | GoodRx Palynziq Price |
| United Kingdom | £20,000 | NHS Palynziq Price |
| Canada | $23,000 | Canada Drugs Palynziq Price |
| Australia | $24,000 | PBS Palynziq Price |
| India | ₹1,800,000 | 1mg Palynziq Price |
Top 5 Global Brands
- Palynziq (BioMarin Pharmaceutical Inc.): The primary and most recognized brand for pegvaliase, used in the treatment of PKU.
- Kuvan (BioMarin Pharmaceutical Inc.): Another medication for PKU, primarily for those who respond to tetrahydrobiopterin (BH4) therapy.
- PKU Sphere (Vitaflo): A nutritional supplement used in managing PKU.
- PhenylAde (Nutricia): A range of nutritional products designed for individuals with PKU.
- Glycomacropeptide (GMP) products (Cambrooke Therapeutics): Protein substitutes for individuals with PKU.