paxlovid 150mg +100mg film-coated tablets


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How It Works

Paxlovid is an oral antiviral medication used to treat COVID-19. It is a combination of nirmatrelvir (150mg) and ritonavir (100mg). Nirmatrelvir inhibits the SARS-CoV-2 main protease (Mpro), an enzyme essential for viral replication. By inhibiting this protease, nirmatrelvir prevents the virus from replicating within the body. Ritonavir, on the other hand, is included to boost the levels of nirmatrelvir by inhibiting the enzyme CYP3A4, which breaks down nirmatrelvir in the liver. This combination allows for higher and more sustained levels of nirmatrelvir, enhancing its antiviral efficacy.

List of Side Effects

  • Altered taste
  • Diarrhea
  • Hypertension
  • Muscle aches
  • Headache
  • Nausea
  • Vomiting
  • Abdominal pain
  • Fatigue
  • Rash
  • Allergic reactions
  • Elevated liver enzymes

List of Indications

  • Treatment of mild-to-moderate COVID-19 in adults and pediatric patients (12 years of age and older weighing at least 40 kg) who are at high risk for progressing to severe COVID-19, including hospitalization or death.

List of Contraindications

  • Known hypersensitivity to nirmatrelvir, ritonavir, or any of the components of the product
  • Severe hepatic impairment
  • Severe renal impairment without dose adjustment
  • Concomitant use with drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious or life-threatening reactions
  • Concomitant use with potent CYP3A inducers where significantly reduced nirmatrelvir or ritonavir plasma concentrations may be associated with the loss of virologic response and possible resistance

Price in Different Countries

Country Price (USD) Reference Website
United States $530 GoodRx
United Kingdom ?400 NICE BNF
Canada $700 CAD
Australia $750 AUD PBS Australia
India ?40,000 INR 1mg
Pakistan ? 90,000 PKR

Top 5 Global Brands

  1. Paxlovid (Nirmatrelvir + Ritonavir) – Pfizer
  2. Molnupiravir – Merck
  3. Remdesivir – Gilead Sciences
  4. Regkirona (Regdanvimab) – Celltrion
  5. Evusheld (Tixagevimab and Cilgavimab) – AstraZeneca
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