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  • PERJETA 420 MG/ 14 ML IV

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    Description

    Perjeta (generic name: Pertuzumab) is a targeted therapy used primarily in the treatment of breast cancer. It is a monoclonal antibody that inhibits a specific protein involved in cancer cell growth. Perjeta is typically used in combination with other medications to enhance its efficacy in treating HER2-positive breast cancer.

    How Perjeta Works

    Mechanism of Action

    1. HER2 Inhibition:
      • Perjeta targets and binds to the HER2 (human epidermal growth factor receptor 2) protein on the surface of cancer cells. HER2 is a receptor that, when overexpressed, promotes cancer cell growth. By blocking HER2, Perjeta interferes with the signaling pathways that drive tumor growth.
    2. Prevention of Dimerization:
      • Perjeta prevents the dimerization (pairing) of HER2 with other HER family receptors, particularly HER3. This dimerization is essential for activating signaling pathways that lead to tumor growth and proliferation. By inhibiting this process, Perjeta effectively disrupts these pathways.
    3. Enhanced Immune Response:
      • The binding of Perjeta to HER2 also marks cancer cells for destruction by the immune system. This helps the body’s natural defenses to better recognize and attack the cancer cells.

    Side Effects

    Common Side Effects

    • Diarrhea:
      • Diarrhea is a frequent side effect that can vary in severity and often requires supportive treatment.
    • Rash:
      • Skin rashes, including dryness and itching, may occur and usually resolve with time or topical treatments.
    • Fatigue:
      • Patients may experience general tiredness and weakness, which can affect daily activities.
    • Nausea:
      • Some individuals may feel nauseous, which can be managed with anti-nausea medications.
    • Hair Loss:
      • Hair loss, or alopecia, is a common issue that can impact patients undergoing treatment.

    Serious Side Effects

    • Heart Problems:
      • Perjeta can cause heart problems, including decreased heart function and congestive heart failure. Regular monitoring of heart function is required during treatment.
    • Infusion-Related Reactions:
      • Reactions during infusion, such as fever, chills, or difficulty breathing, may occur and require immediate medical attention.
    • Infections:
      • Increased risk of infections due to a weakened immune system can occur, necessitating vigilance and potential prophylactic treatments.
    • Allergic Reactions:
      • Severe allergic reactions, such as anaphylaxis, may occur, which require prompt medical intervention.

    Indications

    Perjeta is indicated for the treatment of:
    • HER2-Positive Breast Cancer:
      • Used in combination with trastuzumab (Herceptin) and chemotherapy for the treatment of early-stage HER2-positive breast cancer.
    • Metastatic HER2-Positive Breast Cancer:
      • Used in combination with trastuzumab and docetaxel for the treatment of HER2-positive breast cancer that has spread to other parts of the body.

    Contraindications

    Perjeta should not be used in the following conditions:
    • Hypersensitivity:
      • Known hypersensitivity to pertuzumab or any of its components.
    • Severe Heart Conditions:
      • Patients with severe heart conditions or significant heart dysfunction should avoid Perjeta due to the risk of exacerbating these conditions.
    • Pregnancy:
      • Perjeta is contraindicated in pregnant women due to potential harm to the fetus. Women of childbearing age should use effective contraception during treatment.
    • Active Infections:
      • Patients with active infections may need to delay treatment until the infection is resolved.

    Price in Different Countries

    The price of Perjeta 420 mg/14 ml IV varies by country and healthcare system. Below is a table showing approximate price ranges in various countries.
    Country Price (Per 420 mg/14 ml Injection) Reference
    United States $7,000 – $8,000 GoodRx
    United Kingdom £5,500 – £6,500 NHS UK
    Canada CAD $8,000 – $9,000 Health Canada
    Australia AUD $10,000 – $12,000 PBS Australia
    India ₹500,000 – ₹600,000 Medlife

    Top 5 Global Brands

    1. Perjeta – Genentech:
      • The original manufacturer of pertuzumab, known for its high efficacy in treating HER2-positive breast cancer.
    2. Perjeta – Roche:
      • Roche is the global pharmaceutical company that markets Perjeta worldwide.
    3. Pertuzumab – Mylan:
      • A prominent generic version of Perjeta offering a more affordable option.
    4. Pertuzumab – Teva:
      • Another reputable manufacturer providing generic pertuzumab.
    5. Pertuzumab – Sandoz:
      • Provides a cost-effective generic alternative to the brand name Perjeta.
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    PERJETA 420 MG/ 14 ML IV
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